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Antidepressant

Wellbutrin + Lithium a/o Epival + Sham rTMS for Bipolar Disorder

Phase 4
Waitlist Available
Led By Theodore Kolivakis, MD
Research Sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

Study Summary

The purpose of this study is to evaluate whether repetitive transcranial magnetic stimulation (rTMS) treatment is an effective adjunct treatment to mood stabilizers and Bupropion.

Eligible Conditions
  • Bipolar Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Montgomery-Asberg Depression Rating Scale (MADRS) from baseline at 8 weeks
Secondary outcome measures
Alcohol use disorder identification test (AUDIT Assessment)
Change in Beck Depression Inventory (BDI-II) from baseline at 8 weeks
Change in Young Mania Rating Scale (YMRS) from baseline at 8 weeks
+2 more

Trial Design

3Treatment groups
Experimental Treatment
Group I: Wellbutrin + Lithium a/o Epival + Sham rTMSExperimental Treatment2 Interventions
Group II: Wellbutrin + Lithium a/o Epival + Active rTMSExperimental Treatment2 Interventions
Group III: Placebo + Lithium a/o Epival + Active rTMSExperimental Treatment2 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sham repetitive transcranial magnetic stimulation
2018
Completed Phase 2
~490
Active Repetitive Transcranial Magnetic Stimulation
2010
N/A
~20
Bupropion
FDA approved

Find a Location

Who is running the clinical trial?

McGill University Health Centre/Research Institute of the McGill University Health CentreLead Sponsor
447 Previous Clinical Trials
159,707 Total Patients Enrolled
Theodore Kolivakis, MDPrincipal InvestigatorMcGill University Health Centre/Research Institute of the McGill University Health Centre
Nancy CP Low, MDPrincipal InvestigatorMcGill University Health Centre/Research Institute of the McGill University Health Centre

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression
Pablo Cervantes 2014. "Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01583023.
All > Transcranial Magnetic Stimulation > Wellbutrin
~4 spots leftby May 2025
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