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Barbiturate

Methohexital for Atrial Fibrillation

Phase 4
Waitlist Available
Led By Elijah Beaty, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients who present to Wake Forest Baptist Medical Center for a direct current cardioversion for treatment of paroxysmal or persistent atrial fibrillation as well as atrial flutter.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1: at induction, prior to first shock, and 1 minute, 3 minutes, 5 minutes, 7 minutes, 9 minutes, 10 minutes, 15 minutes, 20 minutes and 30 minutes after first cardioversion
Awards & highlights

Study Summary

This trial found that methohexital was as effective and safe as propofol for direct current cardioversion.

Eligible Conditions
  • Atrial Fibrillation
  • Atrial Flutter

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1: at induction, prior to first shock, and 1 minute, 3 minutes, 5 minutes, 7 minutes, 9 minutes, 10 minutes, 15 minutes, 20 minutes and 30 minutes after first cardioversion
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1: at induction, prior to first shock, and 1 minute, 3 minutes, 5 minutes, 7 minutes, 9 minutes, 10 minutes, 15 minutes, 20 minutes and 30 minutes after first cardioversion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time From Initiation of Sedation to Full Recovery
Secondary outcome measures
Diastolic Blood Pressure
Heart Rate
Mean Arterial Blood Pressure
+8 more

Side effects data

From 2022 Phase 4 trial • 73 Patients • NCT04187196
32%
Bradycardia
16%
Jaw thrust or chin lift
16%
Apnea >20 seconds
11%
Hypotension
100%
80%
60%
40%
20%
0%
Study treatment Arm
Sedation With Methohexital Group
Sedation With Propofol Group

Trial Design

2Treatment groups
Experimental Treatment
Group I: Sedation with propofol groupExperimental Treatment1 Intervention
Participants in this group will be randomized to sedation with bolus dosing of propofol for cardioversion.
Group II: Sedation with methohexital groupExperimental Treatment1 Intervention
Participants in this group will be randomized to sedation with bolus dosing of methohexital for cardioversion.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Propofol
2017
Completed Phase 4
~1530
Methohexital
2011
Completed Phase 4
~240

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,238 Previous Clinical Trials
1,004,030 Total Patients Enrolled
1 Trials studying Atrial Fibrillation
219 Patients Enrolled for Atrial Fibrillation
Elijah Beaty, MDPrincipal InvestigatorWake Forest University Health Sciences

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Journal of the American Heart AssociationJournal
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion
Beaty, Elijah H., Rohesh J. Fernando, Marie L. Jacobs, Gillian G. Winter, Catalina Bulla, Matthew J. Singleton, Neel J. Patel, Natalie S. Bradford, Prashant D. Bhave, and Roger L. Royster. 2022. “Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion”. Journal of the American Heart Association. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/jaha.122.026198.
clinicaltrials.govStudy
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion
2020. "Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04187196.
~15 spots leftby Apr 2025
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