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Antiplatelet Agent
ASA and Celecoxib for Rheumatoid Arthritis
Phase 4
Recruiting
Research Sponsored by Inova Health Care Services
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Inclusion Criteria:Qualified patients should have all 4 main criteria
Age 18-75 years of age for patients who regularly use NSAIDs.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights
Study Summary
The objectives of this single site, randomized, crossover study is to evaluate the pharmacodynamic interactions between aspirin, NSAIDs and Coxibs with respect to platelet function, biomarkers of inflammation and endothelial function.
Eligible Conditions
- Rheumatoid Arthritis
- Cardiovascular Disease
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Platelet aggregation
Secondary outcome measures
Endothelial function by EndoPAT
Oxidized LDL
Serum TxB2
+4 moreTrial Design
2Treatment groups
Active Control
Group I: ASA and CelecoxibActive Control2 Interventions
Take celecoxib 200mg capsule twice a day and aspirin 81mg tablet once a day for 4 weeks (after completion of the run-in period)
Group II: ASA and NaproxenActive Control2 Interventions
Take naproxen sodium 550mg tablet twice a day and aspirin 81mg tablet once a day (after completion of the run-in period)
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Who is running the clinical trial?
Inova Health Care ServicesLead Sponsor
69 Previous Clinical Trials
22,229 Total Patients Enrolled
Kevin Bliden, BS, MBAStudy DirectorInova Health Care Services
Frequently Asked Questions
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