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Hormone Therapy

Arm 1 for Menopause

Phase 4
Waitlist Available
Led By Howard Hodis, MD
Research Sponsored by Kronos Longevity Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured at screening, 12, 24, 36, and 48 months
Awards & highlights

Study Summary

The study will examine the effects of estrogen and progesterone on the development of atherosclerosis in menopausal women when hormone treatment is initiated within 3 years of the menopausal transition.

Eligible Conditions
  • Menopause
  • Hardening of the Arteries

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured at screening, 12, 24, 36, and 48 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at screening, 12, 24, 36, and 48 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of change of carotid intimal medial thickness by ultrasound
Secondary outcome measures
Blood clotting factors
Change in coronary calcium score by X-ray tomography
Cognitive and Affective scores on standard psychometric tests
+4 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Arm 1Active Control4 Interventions
CEE 0.45 mg w/ Prometrium 200 mg patch 0.05 mg w/ Prometrium 200 mg
Group II: Arm 2Placebo Group2 Interventions
Placebo patch, placebo CEE, placebo Prometrium

Find a Location

Who is running the clinical trial?

University of UtahOTHER
1,098 Previous Clinical Trials
1,777,902 Total Patients Enrolled
1 Trials studying Menopause
58 Patients Enrolled for Menopause
University of WashingtonOTHER
1,738 Previous Clinical Trials
1,843,623 Total Patients Enrolled
2 Trials studying Menopause
422 Patients Enrolled for Menopause
University of California, San FranciscoOTHER
2,503 Previous Clinical Trials
15,235,927 Total Patients Enrolled
2 Trials studying Menopause
36 Patients Enrolled for Menopause

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Kronos Early Estrogen Prevention Study (KEEPS)
2005. "Kronos Early Estrogen Prevention Study (KEEPS)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00154180.
All > Prevention
~37 spots leftby Apr 2025
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