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Vasopressin Analog

Desmopressin for Bedwetting

Phase 4

Waitlist Available

Led By Kerry Morrone, MD

Research Sponsored by Montefiore Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and 4 weeks

Awards & highlights

Study Summary

This trial will see if desmopressin helps sickle cell patients stop nighttime bedwetting.

Eligible Conditions

Bedwetting
Sickle Cell Anemia

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and 4 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and 4 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Bedwetting episodes

Secondary outcome measures

Change in Daytime Fatigue

Change in Nighttime awakenings

Impact of Bedwetting on day to day activities

Side effects data

From 2012 Phase 3 trial • 395 Patients • NCT01262456

Headache

Hyponatraemia

Osteoarthritis

Acute myocardial infarction

100%

80%

60%

40%

20%

Study treatment Arm

Desmopressin 50 μg Double-Blind

Desmopressin 75 μg Double-Blind

Placebo Double-Blind

Desmopressin 50 μg Double-Blind / 100 μg Open-Label

Desmopressin 75 μg Double-Blind / 100 μg Open-Label

Placebo Double-Blind / Desmopressin 100 μg Open-Label

Trial Design

1Treatment groups

Experimental Treatment

Group I: Treatment GroupExperimental Treatment1 Intervention

Desmopressin 0.2mg tablets, dose titrated to effect

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Desmopressin

2010

Completed Phase 4

~3990

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Montefiore Medical CenterLead Sponsor

441 Previous Clinical Trials

582,189 Total Patients Enrolled

Kerry Morrone, MDPrincipal Investigator - Montefiore Medical Center

Children's Hospital at Montefiore, The, Montefiore Medical Center, Montefiore Medical Center-North

1 Previous Clinical Trials

3 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are presently enrolling volunteers for the trial?

"Clinicaltrials.gov denotes that this study, initially posted on July 7th 2020, is presently recruiting patients. The trial has been edited as recently as May 25th 2022."

Answered by AI

Who is eligible to join this research project?

"In order to be eligible for this trial, one must suffer from nocturnal enuresis and should lie between 8-21 years of age. The study is currently accepting around 60 participants."

Answered by AI

Are there any documented precedents of research involving Desmopressin?

"Presently, there is one active clinical trial assessing the efficacy of Desmopressin. This medical investigation has yet to reach Phase 3 and is predominantly located in Bronx, New york with a single additional site."

Answered by AI

Is the age range for participants in this trial inclusive of individuals over 75 years old?

"According to the study parameters, individuals eligible for this trial must be between 8 and 21 years old. Meanwhile, there are 148 studies open for participants younger than 18 and 214 trials available for those over 65."

Answered by AI

What indications is Desmopressin typically used to treat?

"Desmopressin may prove beneficial in treating von willebrand disease, as well as haemorrhaging and polyuria."

Answered by AI

How many participants are currently enrolled in this scientific research?

"Affirmative. According to clinicaltrials.gov, this research study is actively enrolling members of the public after its original posting on July 7th 2020 and latest update on May 25th 2022. To complete their experiment, the team needs 60 participants from a single site."

Answered by AI

Is Desmopressin a viable option for medical treatment with minimal risk?

"The safety of Desmopressin has been positively established, hence it is assigned a rating of 3. This Phase 4 trial confirms that this medication has already been approved for use."

Answered by AI

Recent research and studies

Archives of Disease in ChildhoodJournal

Nocturnal Enuresis in Sickle Cell Haemoglobinopathies.

Readett, D R, J S Morris, and G R Serjeant. 1990. “Nocturnal Enuresis in Sickle Cell Haemoglobinopathies.”. Archives of Disease in Childhood. BMJ. doi:10.1136/adc.65.3.290.

UrologyJournal

Enuresis Is a Common and Persistent Problem Among Children and Young Adults with Sickle Cell Anemia

Field, Joshua J., Paul F. Austin, Ping An, Yan Yan, and Michael R. DeBaun. 2008. “Enuresis Is a Common and Persistent Problem Among Children and Young Adults with Sickle Cell Anemia”. Urology. Elsevier BV. doi:10.1016/j.urology.2008.02.006.

Journal of Pediatric PsychologyJournal

Nocturnal Enuresis in Sickle Cell: Sociodemographic, Medical, and Quality of Life Factors

Porter, Jerlym S, Andrew J Paladino, Kathryn Russell, Rebecca Rupff, Jamilla Griffith, Yujiao Mai, Hui Zhang, Jane S Hankins, and Winfred C Wang. 2021. “Nocturnal Enuresis in Sickle Cell: Sociodemographic, Medical, and Quality of Life Factors”. Journal of Pediatric Psychology. Oxford University Press (OUP). doi:10.1093/jpepsy/jsab079.

Journal of UrologyJournal