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General Anesthetic

MTPI vs Classic Induction for Anesthesia

Phase 4
Recruiting
Led By Lauren M Nakazawa, MD, MBA
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after 3 failed intubation attempts (less than 7 minutes from start of intubation)
Awards & highlights

Study Summary

This trial will compare the efficiency of tracheal intubation using two different induction techniques, as well as evaluate for potential adverse events.

Who is the study for?
This trial is for individuals with a BMI over 30 or a Mallampati score of III or IV who need general anesthesia and tracheal intubation. It's not suitable for those with severe respiratory conditions, high-risk physical status, emergency surgery needs, specific induction requirements, pregnancy, untreated heart disease, contraindications to mask ventilation, or allergies to the drugs used.Check my eligibility
What is being tested?
The study aims to compare two methods of inducing anesthesia: Modified Time Principle Induction (MTPI) versus Classic Induction (CI). It will evaluate how well each method prepares patients for tracheal intubation and monitor any adverse effects that may occur during the process.See study design
What are the potential side effects?
Potential side effects from the anesthetic drugs propofol and rocuronium include allergic reactions, breathing difficulties, low blood pressure, nausea or vomiting. The severity of side effects can vary based on individual patient factors.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and during surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The total time between laryngoscope insertion into mouth and the onset of ventilation after tracheal intubation
Secondary outcome measures
Airway view at the time of laryngoscopy as categorized by the modified Cormack-Lehane classification (before external manipulation)
Diastolic blood pressure
End-tidal carbon dioxide (CO2) level
+14 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: MTPI groupExperimental Treatment1 Intervention
Group II: Classic Induction groupActive Control1 Intervention

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor
903 Previous Clinical Trials
320,834 Total Patients Enrolled
Lauren M Nakazawa, MD, MBAPrincipal InvestigatorThe University of Texas Health Science Center, Houston

Media Library

Classic Induction (General Anesthetic) Clinical Trial Eligibility Overview. Trial Name: NCT05509192 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction
Lauren Nakazawa 2022. "Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05509192.
~54 spots leftby Apr 2025
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