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Opioid Analgesic

Spinal Morphine for Anesthesia

Phase 4

Recruiting

Led By Engy T Said, MD

Research Sponsored by University of California, San Diego

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up post-operative day 0, 1, 2, 3, 4, 14, 30

Awards & highlights

Study Summary

This trial found that, for patients undergoing hepatic resection, the addition of ESP catheters to an existing multimodal analgesic regimen that included intrathecal morphine provided superior postoperative analgesia compared to patients who did not receive ESP catheters.

Eligible Conditions

Anesthesia
Local Anesthesia
Acute Pain
Liver Resection

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ post-operative day 0, 1, 2, 3, 4, 14, 30

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~post-operative day 0, 1, 2, 3, 4, 14, 30

This trial's timeline: 3 weeks for screening, Varies for treatment, and post-operative day 0, 1, 2, 3, 4, 14, 30 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Total opioid requirement postoperative day (POD) 1-3

Secondary outcome measures

Discharge opioids and refills.

Hospital Length Of Stay

Nausea

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active TreatmentExperimental Treatment2 Interventions

This group will receive a continuous erector spinae block catheter followed by an infusion of ropivacaine 0.2% at 10ml automatic set bolus per 120 minutes with 2ml/hr continuous infusion (14mls total every 2 hours per catheter)

Group II: PlaceboPlacebo Group2 Interventions

This group will receive a superficially placed (taped to the surface) erector spinae block catheter with a ropivacaine 0.2% infusion at 0.1ml /hr

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Spinal Morphine

2023

Completed Phase 4

~170

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor

1,120 Previous Clinical Trials

1,521,565 Total Patients Enrolled

Engy T Said, MDPrincipal InvestigatorUniversity of California, San Diego

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment for this clinical trial still open to volunteers?

"Correct. According to the information on clinicaltrials.gov, this study is currently in its recruitment phase having been initially posted on May 24th 2021 and last edited on June 6th 2022. 70 participants are being sought from one location."

Answered by AI

To what ailment has 0.2% ropivacaine local anesthetic continuous erector spinae plane block shown to be a viable remedy?

"Administered as a continuous erector spinae plane block, 0.2% ropivacaine local anesthetic can be advantageous for anesthesia procedures, pain management, and labor induction."

Answered by AI

What potential adverse reactions might patients experience from 0.2% ropivacaine local anesthetic continuous erector spinae plane block?

"With Phase 4 trials already completed, 0.2% ropivacaine local anesthetic continuous erector spinae plane block has been assessed to have a safety rating of 3 on our Power scale."

Answered by AI

What prior research has there been on the effects of administering 0.2% ropivacaine local anesthetic through erector spinae plane block?

"Currently, 118 clinical trials are ongoing for 0.2% ropivacaine local anesthetic continuous erector spinae plane block with 29 of those in the final phase. Primarily located in Boston, Massachusetts, there exist 213 medical centres conducting studies surrounding this treatment."

Answered by AI

What is the scope of enrolment for this clinical trial?

"Affirmative. The clinicaltrials.gov database declares that this medical experiment commenced on May 24th 2021 and is still in the process of recruitment as recent as June 6th 2022; 70 patients are being sought at one site."

Answered by AI

Recent research and studies

A & A PracticeJournal

Erector Spinae Plane Blocks in Major Hepatopancreaticobiliary Surgery

Nair, Shrijit, Siobhan McGuinness, Fouad Masood, John F. Boylan, and Niamh P. Conlon. 2019. “Erector Spinae Plane Blocks in Major Hepatopancreaticobiliary Surgery”. A & A Practice. Ovid Technologies (Wolters Kluwer Health). doi:10.1213/xaa.0000000000001069.

Anesthesia & AnalgesiaJournal

The Use of Intrathecal Morphine for Postoperative Pain Relief After Liver Resection: A Comparison with Epidural Analgesia

De Pietri, Lesley, Antonio Siniscalchi, Alexia Reggiani, Michele Masetti, Bruno Begliomini, Matteo Gazzi, Giorgio E. Gerunda, and Alberto Pasetto. 2006. “The Use of Intrathecal Morphine for Postoperative Pain Relief After Liver Resection: A Comparison with Epidural Analgesia”. Anesthesia & Analgesia. Ovid Technologies (Wolters Kluwer Health). doi:10.1213/01.ane.0000198567.85040.ce.

Anesthesia & AnalgesiaJournal

The Use of Intrathecal Morphine for Postoperative Pain Relief After Liver Resection: A Comparison with Epidural Analgesia

clinicaltrials.govStudy

Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection