← Back to Search

Retinoid

Trifarotene Cream for Acne (START Trial)

Phase 4
Waitlist Available
Research Sponsored by Galderma R&D
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 24
Awards & highlights

START Trial Summary

This trial will test if a new acne cream can help reduce the risk of developing scars from acne.

START Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 24
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 24 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Absolute Change From Baseline in Total Atrophic Acne Scar Count Per Half Face at Week 24
Secondary outcome measures
Absolute Change from Baseline in Total Atrophic Acne Scar Count Per Half-Face to Week 20
Total Atrophic Acne Scar Count Per Half-Face From Baseline to Week 24

Side effects data

From 2022 Phase 4 trial • 123 Patients • NCT05089708
5%
COVID-19
3%
Nasopharyngitis
3%
Influenza
2%
Attention deficit hyperactivity disorder
2%
Muscle spasms
2%
Vomiting
2%
Oropharyngeal pain
100%
80%
60%
40%
20%
0%
Study treatment Arm
Trifarotene (CD5789) Cream
Trifarotene Vehicle Cream

START Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Trifarotene (CD5789) 50 mcg/g CreamExperimental Treatment1 Intervention
Group II: Trifarotene Vehicle CreamPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Trifarotene Cream
2021
Completed Phase 4
~250

Find a Location

Who is running the clinical trial?

Galderma R&DLead Sponsor
297 Previous Clinical Trials
60,147 Total Patients Enrolled
11 Trials studying Acne
1,464 Patients Enrolled for Acne

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical trial possess any precedent in the medical community?

"Two studies are presently being conducted with Trifarotene Cream in 34 cities across four nations. In 2021, 118 patients participated in the Phase 4 trial of this Galderma R&D-sponsored medication and since then seven other clinical trials have concluded."

Answered by AI

In how many facilities can patients receive access to this clinical trial?

"At this moment, there are 17 different clinical sites in the United States of America that are willing to enroll patients for this trial. These locations span from Las Vegas to Snellville and Darien; so you can easily find a centre closest to your residence if you decide to participate."

Answered by AI

Are there any opportunities to join this clinical experiment at present?

"Current information supplied by clinicaltrials.gov reveals that this study is not presently recruiting individuals. First listed on May 28th 2021, the trial was last edited October 14th 2022. However, 37 other trials are now enrolling patients for participation."

Answered by AI

Does the age restriction for this clinical experiment encompass individuals younger than thirty?

"In order to be considered for the trial, potential participants must fall between 17 and 35 years of age."

Answered by AI

How many eligible participants are accepted into this medical trial?

"At this moment, no further patients are being sought for the study. It was first made available to the public on May 28th 2021 and has been modified most recently on October 14 2022. For those in search of other trials related to acne, 35 studies remain active while two involve Trifarotene Cream directly."

Answered by AI

Has previous research been conducted involving Trifarotene Cream?

"Currently, two trials exploring the use of Trifarotene Cream are in progress. Neither is at Phase 3 yet. Multiple medical centres located mostly around Arlington, Texas are testing this cream and altogether 43 sites across the US have already begun their research."

Answered by AI

What criteria must I meet in order to participate in this experiment?

"This clinical trial aims to recruit 118 subjects, aged 17-35, who are suffering from acne. The following criteria must be met for inclusion: Investigator's Global Assessment (IGA) score of 3 (Moderate) or 4 (Severe), no more than 2 nodules on the face (>1 cm in diameter), a minimum of 20 inflammatory lesions and 10 atrophic scars per half-face; females of childbearing potential must use approved contraceptives to treat acne vulgaris; other specified requirements may apply."

Answered by AI

Is it safe to use Trifarotene Cream as a treatment for patients?

"Trifarotene Cream has been approved and thus, its safety rating is a 3 on our team's scale. This ranks it as one of the most secure treatments in this trial."

Answered by AI

Who else is applying?

What state do they live in?
Nevada
How old are they?
65+
What site did they apply to?
Galderma Investigational Site #8108
What portion of applicants met pre-screening criteria?
Did not meet criteria
~32 spots leftby Apr 2025