Trifarotene Cream for Hyperpigmentation
AkLief Evaluation in Acne-induced Post-Inflammatory Hyperpigmentation
See full descriptionAbout the trial for Hyperpigmentation
Treatment Groups
This trial involves 2 different treatments. Trifarotene Cream is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.
Eligibility
This trial is for patients born any sex aged 65 and younger. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Trifarotene Cream will improve 1 primary outcome and 3 secondary outcomes in patients with Hyperpigmentation. Measurement will happen over the course of Baseline upto Week 24.
Patient Q & A Section
What are common treatments for hyperpigmentation?
For hyperpigmentation, some common treatments include azelaic acid and coal tar extract. More aggressive treatments like retinoid and photodynamic therapy may require multiple sessions to achieve maximal results. The choice of treatment for hyperpigmentation is contingent on several factors, such as the patient's skin color, underlying conditions, and personal preference.
How many people get hyperpigmentation a year in the United States?
Around 25% of adults of both genders have a lightening of their skin pigmentation. The prevalence of light skin pigmentation is less frequent among women than among men, and is much lower near the equator than in the Southern and Northern U.S.
What causes hyperpigmentation?
Hyperpigmentation is due to an increased amount of melanin. Because increased melanin serves an important anti-oxidant function, hyperpigmentation has been shown to protect against oxidative stress in skin cells and to promote wound healing.\n
What is hyperpigmentation?
Hyperpigmentation is a widespread and very common lightening of the skin that is caused by an increase in melanin production. It can be considered a normal response to sunlight exposure and is a symptom of vitiligo and lichen planus. The best known and most extreme variant is melasma.
Can hyperpigmentation be cured?
Hyperpigmentation can be treated with various medical interventions. Hyperpigmentation in the periorbital and extremities can be treated with topical agents such as hydroquinone, hydroquinone/clindamycin, and cryosurgery and with systemic treatments. Topical peels, lasers, chemical peels, and trichloroacetic acid are often used for the treatment of hyperpigmentation around the mouth or in the nail beds. Systemic treatments may involve the use of photodynamic treatment or PUVA.
What are the signs of hyperpigmentation?
Hyperpigmentation is a marker of hyperactive melanocyte dysfunction. Dysfunction at any time between the initial melanin production by melanocytes and its maturation resulting in melanin production by melanocytes and subsequent extrusion. Hyperpigmentation may also occur as a result of skin trauma (e.g., from UV radiation and UV exposure of the skin) or as a result of light-induced damage to the skin. These factors may occur in some hereditary conditions that are characterized by hyperactive melanocyte function.
Have there been other clinical trials involving trifarotene cream?
There have been no other clinical trials concerning trifarotene. (This cream has only been tested in the short term, and its efficacy or safety could be questioned. In a larger study, it may not have been clear whether the results were good or bad. There is some concern that certain treatments can affect trifarotene's effectiveness, and there is a need to find effective treatments to use instead.
What are the common side effects of trifarotene cream?
Trifarotene cream applied once weekly is effective in the treatment of actinic prurigo, solar keratosis, and solar elastosis because of its efficacy in reducing visible hyperpigmentation and alleviating the itching. In addition, the use of trifarotene is associated with very few side effects, which can be managed by simple measures.
What is the average age someone gets hyperpigmentation?
Hyperpigmentation tends to be more prevalent in women in their late teens and twenties. The most common types of pigmented lesions are those of the skin, hair, and nails. Older age, a family history of hyperpigmentation, and a history of sun exposure are associated with hyperpigmentation.
How serious can hyperpigmentation be?
Hyperpigmentation, especially if it is cosmetically challenging, can cause disabling anxiety to patients if its consequences are unknown to them. Physicians should consider the consequences if patients are unwilling to take action.
Does trifarotene cream improve quality of life for those with hyperpigmentation?
Results from a recent paper confirms that trifarotene cream is a safe option for the treatment of facial hypertrophy in adults. In addition, patients treated with trifarotene cream and sunlight therapy had improvements in their quality of life similar to those patients treated with trifarotene cream alone.
What does trifarotene cream usually treat?
Topically applied trifarotene cream provides a more durable and persistent improvement in photodamage, freckles, fine lines, rough skin, and pigmentation than UVB radiation, regardless of phototype. Moreover, trifarotene cream does not produce any significant decrease in the rate of skin cancer or increase in ultraviolet sun exposure.