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Vaccine

Fluad Vaccine for Influenza

Phase 4
Waitlist Available
Led By David Canaday, MD
Research Sponsored by David H. Canaday
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6-8 months post vaccine administration
Awards & highlights

Study Summary

This trial found that adjuvanted flu vaccine, Fluad, is just as effective as HD influenza vaccine in older people living in long-term care.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6-8 months post vaccine administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6-8 months post vaccine administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Non-inferiority in overall hemagglutinin inhibition (HAI) titer and seroconversion rate between FLUAD and FLUZONE HD at 1 month post-vaccination will be determined.
Secondary outcome measures
Heterologous immunity at 1 month post-vaccination will be compared between FLUAD and FLUZONE HD.
Non-inferiority in overall neuraminidase inhibition (NAI) titer and seroconversion rate between FLUAD and FLUZONE HD at 1 month post-vaccination will be determined.
Non-inferiority in overall serum virus neutralization (SVN) assays titer and seroconversion rate between FLUAD and FLUZONE HD at 1 month post-vaccination will be determined.
Other outcome measures
To Pilot clinical objective: Efficacy of FLUAD will be compared to FLUZONE HD.

Trial Design

2Treatment groups
Active Control
Group I: Fluad VaccineActive Control1 Intervention
A single adjuvanted dose (AD) intramuscular injection
Group II: Fluzone VaccineActive Control1 Intervention
A single high dose (HD) intramuscular injection

Find a Location

Who is running the clinical trial?

David H. CanadayLead Sponsor
Case Western Reserve UniversityOTHER
299 Previous Clinical Trials
246,104 Total Patients Enrolled
Brown UniversityOTHER
456 Previous Clinical Trials
557,876 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has the Fluad Vaccine been officially validated by the FDA?

"The Fluad Vaccine has been approved, so it is perceived to have a safety level of 3 on our team's rating scale."

Answered by AI

What is the current enrollment for this research project?

"Unfortunately, this medical trial has ceased recruitment and is no longer seeking candidates. It was initially posted on September 23rd 2018 and the last edit ocurred on May 20th 2022. However, there are currently 63 studies actively enrolling those suffering from influenza-induced flu and 14 trials using Fluad Vaccine that welcome new participants."

Answered by AI

Is recruitment for the trial still open to new participants?

"As per information on clinicaltrials.gov, this research project is no longer accepting volunteers as recruitment concluded on May 20th 2022. The trial was initially posted September 23rd 2018. Nevertheless, there are currently 77 other studies recruiting participants at the moment."

Answered by AI

Are there any documented experiments that have employed Fluad Vaccine?

"Currently, 14 clinical trials are underway for the Fluad Vaccine. Of these studies, 1 is in its final phase of development; Phase 3. While most sites recruiting patients are based in Miami, Florida there exist 15 other locations conducting research on this vaccine."

Answered by AI

Is this trial the inaugural experiment of its variety?

"At the moment, 14 studies involving Fluad Vaccine are active in 10 cities across 3 countries. The first clinical trial of this vaccine was conducted by Pharmacyclics LLC and concluded its Phase 2 approval stage with 42 enrolled patients in 2016. Since then, 159 related trials have been finalised."

Answered by AI
Recent research and studies
~73 spots leftby Apr 2025