Miacalcin Calcitonin Salmon Nasal Spray for Pelvic Ring Fractures

A pelvis fracture may be caused by an unexpected fall. The injury may be isolated to the pelvis, with the rest of the body unaffected, or may be severe enough to interfere with breathing and circulation.\n

Nonoperatively (observation). Patients with unstable pelvic ring fractures that were not treated can be discharged with a successful outcome. Operatively (internal fixation). A good surgical technique and a short hospital stay should result in a good recovery. Even in patients with unstable pelvic ring fractures, we recommend an urgent surgical approach.

This is a complex area to address. Fractum care is highly contextual and dependent on local circumstances. The fracture-set should be completed early in order to minimize disability and maximize return to work. Anesthesiology is critical in determining morbidity in pelvic ring fractures as a high quality trauma care may decrease complications and increase functional outcomes.

Our survey of the literature showed limited data on the epidemiology of pelvic ring injuries and of long-term complications of pelvic ring injuries. Despite some data that are compatible with the hypothesis of an increasing use of traction devices for pelvic ring trauma, the number of pelvic trauma in our cohort of patients (25,000) was low.

All three pelvic ring injuries are associated with pain, usually radicular to the pelvic bone and surrounding soft tissue. Pelvic injury pain cannot be explained by the anatomical landmarks of injury, and there is usually a decrease in strength, but not a loss of sensation.

Each month, around 1733 women get pelvic ring fractures in the United States, making up 4.9% of American women. During 2010-2014, the mean age of women sustaining a pelvic ring fracture was around 63.2 years, about 4.4 years younger than the average age of American women, 67.6 years old. However, only 23.9% of women actually received the treatment they needed, mostly due to lack of finances. This puts them at great medical risk, since a pelvic ring fracture can make pelvic fractures and infertility much more common in older women.

The long-term results of nasal spray acalcitonin show that calcitonin is efficacious, with some degree of safety. In-hospital treatment of calcitonin in high-risk patients, in our experience, does not worsen outcome. Because acalcitonin is a well-tolerated and effective treatment option, it should, in our opinion, be considered in the treatment of patients with acute severe PNF.

Miacalcin calcitonin nasal spray is associated with adverse effects that may be dose dependent. Most (70%) of the patients in the study reported nasal irritation or a sensation of congestion. Nasal congestion was the most common adverse event reported, occurring in 35% of all patients. Injection site pain occurred in 20% of patients. Painful injection site erythema occurred in 29% of patients. All adverse events were predominantly mild to moderate and of short duration. No drug-related illnesses were reported to occur in the study participants.

Results from a recent clinical trial show no evidence for beneficial effects of MC-CAL and its combination with other treatments on the management of chronic pelvic pain.

Intranasal miacalcin salmon calcitonin improves HRQoL in women with pelvic ring fractures that persists for at least three months in conjunction with a standard post-operative care program.

Patients with PFL injuries are not usually life-threatening. The average length of stay is 2 weeks, although the outcomes appear to be worse for patients who are female.