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Dexmedetomidine for Anesthesia

Phase 4
Waitlist Available
Led By Keira Mason, MD
Research Sponsored by Boston Children's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 20 minutes
Awards & highlights

Study Summary

This trial is testing whether dexmedetomidine, a sedative, affects the smooth muscle in the anorectal region.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~20 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 20 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Manometry

Side effects data

From 2020 Phase 4 trial • 798 Patients • NCT02004613
57%
Clinically important hypotension
9%
Clinically important bradycardia
1%
infection
1%
stroke
1%
Atelectasis
1%
Hemorrhage
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Dexmedetomidine

Trial Design

1Treatment groups
Experimental Treatment
Group I: DexmedetomidineExperimental Treatment1 Intervention
This is a single arm, open label, interventional study examining the effects of dexmedetomidine on anal manometry. All subjects will be administered dexmedetomidine following their baseline manometry measurements. Following dexmedetomidine administration, anal manometry measurements will be observed for 15 minutes.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexmedetomidine
FDA approved

Find a Location

Who is running the clinical trial?

Boston Children's HospitalLead Sponsor
760 Previous Clinical Trials
5,579,658 Total Patients Enrolled
Keira Mason, MDPrincipal Investigator - Boston Children's Hospital
Boston Children's Hospital
5 Previous Clinical Trials
243 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you elucidate the potential risks of Dexmedetomidine intake?

"After careful analysis, our team at Power has rated the safety of Dexmedetomidine a 3 due to Phase 4 trials that have already been conducted. This indicates that this treatment is approved and safe for use."

Answered by AI

Who is qualified to join this experiment?

"This medical trial is accepting 25 minors aged between 3 and 18 who are willing to undertake anorectal manometry unaided by sedation (barring pre-med midazolam). The participants must be scheduled for upper or lower procedures at Boston Children's Hospital, consent to the study in writing, provide pregnancy testing results if female of reproductive age, and accept standard dexmedetomidine/propofol medication during their gastrointestinal procedure at the GPU."

Answered by AI

Is participation in this clinical research still available for those interested?

"The information available on clinicaltrials.gov confirms that this trial is actively enrolling participants at present. It was initially posted in September 2021 and updated most recently, August 2022."

Answered by AI

Can you provide a summary of past trials that have included Dexmedetomidine?

"At present, there are 110 active trials for Dexmedetomidine with 23 in their final Phase. Most of the clinical sites can be found in Karachi, Sindh; however, 207 locations globally are conducting research on Dexmedetomidine's efficacy and safety."

Answered by AI

Is this research project offering participation to those who are younger than 85 years old?

"As per the entry standards of this trial, minors aged 3 to 18 can be considered candidates."

Answered by AI

How many participants are being admitted to the clinical trial?

"Affirmative. Clinicaltrials.gov conveys that this clinical trial, initially posted on September 14th 2021 has resumed its recruitment efforts of 25 patients from a single medical centre."

Answered by AI

What circumstances does Dexmedetomidine typically address?

"Dexmedetomidine can be prescribed to relieve the symptoms of disease, ventilations, mechanical dysfunction and cyclic vomiting syndrome."

Answered by AI
Recent research and studies
~6 spots leftby Apr 2025