Rabbit Anti-Human T-Lymphocyte Globulin Injectable Solution [Thymoglobulin] for Kidney Transplantation

Results from a recent paper, the signs presented with the occurrence of SOT are fever and increased white blood cell count. There are no specific signs of immunosuppression.

Recent findings suggest that many cases of immune failure may be cured with corticosteroid withdrawal. These patients may need close monitoring by immuno-metabolic team following the therapeutic intervention.

There are many definitions of immunosuppression. The most common use is to describe patients on a treatment who are in a prolonged state of cellular or humoral immunosuppression, as in organ or stem cell transplanted patient populations. For a more accurate definition of the term 'immunosuppression', it is necessary to consider patient-specific immunogenetic and cytokine profiles. It is important to recognize the dynamic nature of transplant rejection processes and the need to adopt the appropriate timing of rejection therapy, at which immunosuppressive drugs are withdrawn.

Immune dysfunction in transplant patients likely reflects a combination of infection or medication-associated immunosuppression and other factors, including genetic predisposition. The immunological alterations that occur in transplant transplant patients may be a mechanism for the risk of CMV disease despite current and ongoing medication regimens.

The following have been used to treat immunosuppression:\n- antihistamines to prevent drug hypersensitivity\n- anticonvulsants to prevent or treat seizures\n- corticosteroids to relieve symptoms\n- antibiotics to prevent or treat an infectious disorder\n- dialysis to correct an electrolyte imbalance or remove toxins or solutes from the blood.\n\n- Allergy: antihistamines can prevent allergic reactions in the first place for allergic individuals, and often prevent asthma sufferers from needing to use nonsteroidal anti-inflammatory drugs (NSAIDs) to control symptoms.

Approximately 18 million people in the United States use some sort of immunosuppressive drugs at some point in time. The use of these drugs is growing with the passage of time. However, the use of immunosuppressive agents is still far less than the prevalence of various malignancies we wish to prevent.

There was no reported correlation between clinical variables and detectable serum levels. There was no treatment-related toxicity or side effects. Thymoglobulin induces transient elevation of liver enzymes and decreases platelet counts when it is administered before bone marrow donation. We did not observe any other side effect during the administration of the drug.

ThymoGlobulin-based therapy represents a novel and efficacious modality, in particular in the treatment of autoimmune thrombocytopenic purpura, multiple myeloma, and autoallergy. In fact, the use of ThymoGlobulin is widely recognized due to the high safety profile, ease of use, and low occurrence of side-effects. Moreover, the lack of occurrence of progressive autoimmune side effects observed after the use of Thymoglobulin in humans has been already demonstrated in rabbit models.

Immunosuppressive drugs are the most widely used agents for treating all types of immunodeficiency; however, their risks prohibit these medications as an option in all situations due to their side effects. There is a lack of treatments that have been found to be more effective than currently available medications. [Power(http://www.withpower.com/immunosuppression)]. However, there has been an introduction of a whole number of new therapies that have been developed to treat immunosuppression, such as rituximab, a monoclonal antibody that binds to and kills B cells.

Thymoglobulin can be administered subcutaneously. Clinical effects appear to be comparable to that reported from randomized controlled trials of intrathecal administration. As a consequence of the short intrathecal exposure of T lymphocytes, a higher relapse rate in the intrathecal group, and the transient nature of the clinical effects, thymoglobulin appears better suited to intravenous administration than intrathecal administration. The safety of thymoglobulin and the potential impact of the intrathecal administration of thymoglobulin on clinical outcomes in patients with hematological malignancies and multiple sclerosis are both worthy of ongoing investigation.

To my knowledge this is the first paper to use the WHO categorization of T cell lymphoproliferative diseases, to apply thymoglobulin, and to publish the clinical results of the immunotherapeutic treatment, but I must mention that this kind of treatment, if given during the time of exacerbation of SLE, has previously given good results in the reduction of flares and relapses of the patient in a short time. The therapy for SLE should be chosen after the exclusion of other severe diseases affecting the immune system, as the disease is related to immunosuppression.