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Cohort 1: Control for Healthy Subjects

N/A
Waitlist Available
Led By Paul Glimcher, PhD
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 minutes
Awards & highlights

Study Summary

This trial is investigating the effects of stress on the brain and decision making. They will use a stressor and survey to measure stress, and then do behavioral and MRI tests to see how it affects decisions about rewards and self-control.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Amount in Dollars ($) Participants are Willing to Allocate to Avoid Use of Self-Control during Decision-Making Task
Stress and Adversity Inventory (STRAIN) Overall Severity Score

Trial Design

5Treatment groups
Experimental Treatment
Group I: Cohort 3: M-Turk SurveyExperimental Treatment0 Interventions
Participants in Cohort 3 will access the Amazon Mechanical Turk (M-Turk) platform, where they can search for available surveys ('HITs') to complete for payment on the M-Turk website. After completing the surveys, participants will complete the Stress and Adversity Inventory (STRAIN) questionnaire.
Group II: Cohort 2: Stress Task + fMRIExperimental Treatment2 Interventions
Participants in Cohort 2 randomized to the Stress task will complete the CPT, which requires the continuous submersion of the forearm in ice-water (0-4°C) for 3 minutes in the presence of an experimenter. After the CPT, participants will complete decision-making tasks while being scanned via functional MRI (fMRI). The tasks will involve attending to auditory and/or visual stimuli on a computer. On each trial, different food items and different amounts of time (1-60 minutes) will be presented and participants will be asked to indicate how much they would pay from their $10 study endowment to avoid spending the trial's stated amount of time with the snack food.
Group III: Cohort 2: Control + fMRIExperimental Treatment2 Interventions
Participants in Cohort 2 randomized to the Control group will complete a matching control task to the CPT, which involves continuous submersion of the forearm in warm water, ~30°C, for 3 minutes. After the control CPT, participants will complete decision-making tasks while being scanned via functional MRI (fMRI). The tasks will involve attending to auditory and/or visual stimuli on a computer. On each trial, different food items and different amounts of time (1-60 minutes) will be presented and participants will be asked to indicate how much they would pay from their $10 study endowment to avoid spending the trial's stated amount of time with the snack food.
Group IV: Cohort 1: Stress TaskExperimental Treatment1 Intervention
Participants in Cohort 1 randomized to the stress task will complete the Cold-Pressor Task (CPT), which requires the continuous submersion of the forearm in ice-water (0-4°C) for 3 minutes in the presence of an experimenter. After the CPT, participants will complete a decision-making task. During the decision-making task, participants will do one of the following: evaluate different features of foods/monetary prizes in 'rating trials', choose between pairs or bundles of snack foods in 'choice trials', bid for the chance to win foods/monetary prizes or bid to remove certain foods from their choice menu in 'auction trials', or choose between pairs of monetary lotteries in 'lottery trials'.
Group V: Cohort 1: ControlExperimental Treatment1 Intervention
Participants in Cohort 1 randomized to the Control group will complete a matching control task to the CPT, which involves continuous submersion of the forearm in warm water, ~30°C, for 3 minutes. After the control CPT, participants will complete a decision-making task. During the decision-making task, participants will do one of the following: evaluate different features of foods/monetary prizes in 'rating trials', choose between pairs or bundles of snack foods in 'choice trials', bid for the chance to win foods/monetary prizes or bid to remove certain foods from their choice menu in 'auction trials', or choose between pairs of monetary lotteries in 'lottery trials'.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cold-Pressor Task (CPT)
2019
N/A
~400
fMRI
2019
Completed Phase 3
~1730
Control CPT
2019
N/A
~400

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,369 Previous Clinical Trials
840,238 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,469 Previous Clinical Trials
2,619,012 Total Patients Enrolled
Paul Glimcher, PhDPrincipal InvestigatorNew York Langone Health
1 Previous Clinical Trials
127 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still positions available for volunteers to join this investigation?

"According to the official listing on clinicaltrials.gov this research project is actively recruiting participants, having first been posted in May of 2019 and last updated as recently as July 2022."

Answered by AI

Am I eligible to take part in this experiment?

"In order to participate in this medical trial, potential subjects must be hale and hearty as well as within the age bracket of 18-64. This study is open for enrollment up to 500 individuals."

Answered by AI

Is enrollment for this clinical trial open to individuals aged 20 and above?

"Participants for this study must be between 18 and 64 years of age, according to the predefined inclusion criteria."

Answered by AI

How many individuals is this research endeavor accommodating?

"Affirmative. Clinicaltrials.gov has data indicating that this medical trial, which began enrollment on May 1st 2019, is actively enrolling participants. It requires 500 individuals from a single site to be recruited into the study."

Answered by AI

Who else is applying?

What state do they live in?
New Jersey
New York
How old are they?
18 - 65
What site did they apply to?
NYU Langone Health
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I was a psychology student, am still interested in research.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Neural Mechanisms of Cost and Benefit Integration During Decision-Making, Aim 2: Acute & Lifetime Stress
2019. "Neural Mechanisms of Cost and Benefit Integration During Decision-Making, Aim 2: Acute & Lifetime Stress". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04060966.
~67 spots leftby Apr 2025
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