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Cardiorespiratory fitness training for Sedentary Lifestyle (EXTEND Trial)
N/A
Waitlist Available
Led By Michelle W Voss, PhD
Research Sponsored by Michelle W. Voss
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 24-weeks
Awards & highlights
EXTEND Trial Summary
This trial will help better understand how exercise affects cognitive aging and could lead to new ways to prevent decline.
EXTEND Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 24-weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 24-weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in hippocampal-dependent learning
Secondary outcome measures
Change in cardiorespiratory fitness
Change in hippocampal-cortical functional connectivity
EXTEND Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Cardiorespiratory fitness trainingExperimental Treatment1 Intervention
Cardiorespiratory fitness training will be a 24-week supervised cycling program designed to improve cardiorespiratory fitness, with supervision directly from the research team. All participants will first receive a one-on-one orientation with an exercise training specialist that has been trained by Dr. Gary Pierce in monitoring an exercise program for healthy older adults. Training will start with a 5 minute-warm-up, 20 minutes moderate intensity cycling and 30 minutes light intensity cycling, and 5 minute cool-down per session, for 3 sessions/week. In each additional week, 6 minutes of moderate intensity cycling per session will be added, until the total time for moderate intensity is 50 minutes per session by the start of week 5 (with additional 5 minute warm-up and 5 minute cool-down).
Group II: Functional fitness trainingActive Control1 Intervention
Functional fitness training will be a 24-week supervised exercise program designed to focus on functional flexibility and mobility, with supervision directly from our research team. All participants will first receive a one-on-one orientation with an exercise training specialist that has been trained by Dr. Gary Pierce in monitoring an exercise program for healthy older adults. Training will start with a 5 minute-warm-up, 20 minutes of light intensity cycling and 20 minutes of dynamic stretching to increase range of motion and functional fitness, for 3 sessions/week. In each additional week, additional stretches will be added to maintain variety and improve flexibility of all major muscle groups.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cardiorespiratory fitness training
2018
N/A
~120
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Who is running the clinical trial?
Michelle W. VossLead Sponsor
Michelle W Voss, PhDPrincipal InvestigatorUniversity of Iowa
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You are considered to have a high risk of experiencing a heart-related problem based on guidelines set by the American College of Sports Medicine.You have been diagnosed with a neurological, metabolic, or psychiatric condition, or have had a brain injury that caused loss of consciousness before.You have not exercised for at least 60 minutes a week in the past year.
Research Study Groups:
This trial has the following groups:- Group 1: Cardiorespiratory fitness training
- Group 2: Functional fitness training
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any available slots for participants in this clinical trial?
"Affirmative. According to clinicaltrials.gov, this ongoing medical trial was first announced on May 1st 2018 and is now actively recruiting patients. 120 participants need to be sourced from one centre of operation."
Answered by AI
Is participation in this experiment available to me?
"This clinical trial has an enrolment cap of 120 participants who must have a non-active lifestyle and be between the ages 55 to 80."
Answered by AI
What is the current enrollment capacity for this trial?
"Affirmative, clinicaltrials.gov shows that this research is currently open for registration. Initially posted on May 1st 2018 and last updated on May 21st 2022, the experiment requires 120 participants from one central site to complete it."
Answered by AI
Is this trial limited to participants of a certain age?
"This trial is only available to individuals between the ages of 55 and 80. Alternatively, 2 clinical trials are accessible for children under 18, while 17 studies can be accessed by those over 65."
Answered by AI
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