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Local Anesthetic

Arm A for Local Anesthesia

Phase 4
Waitlist Available
Led By Joseph McBride, MD
Research Sponsored by University of Nebraska
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
adults presenting for routine thyroid biopsy, paracentesis or thoracentesis in interventional radiology
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

The purpose of this study is to determine the optimal amount of lidocaine buffering needed to decrease injection pain when administering local anesthesia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Injection pain

Trial Design

4Treatment groups
Active Control
Group I: Arm AActive Control1 Intervention
10 mg/mL lidocaine; Frequency: 1
Group II: Arm BActive Control2 Interventions
9 mg/mL of 10% sodium bicarbonate-90% lidocaine; Frequency: 1
Group III: Arm CActive Control2 Interventions
7.5 mg/Ml of 25% sodium bicarbonate-75% lidocaine Frequency: 1
Group IV: Arm DActive Control2 Interventions
5 mg/mL 50% sodium bicarbonate-50% lidocaine Frequency: 1

Find a Location

Who is running the clinical trial?

University of NebraskaLead Sponsor
537 Previous Clinical Trials
1,143,884 Total Patients Enrolled
Joseph McBride, MDPrincipal InvestigatorUniversity of Nebraska

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia
Joseph McBride, MD 2016. "Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02647892.
~8 spots leftby Apr 2025
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