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History of Significant Injury for Pain

N/A
Waitlist Available
Research Sponsored by Mount St. Mary's College, Los Angeles, CA
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up data will be collected in one, one hour session. continuous monitoring of hrv will occur during each intervention or condition and significant data points will be marked for future analysis.
Awards & highlights

Study Summary

The prevalence of chronic pain has been estimated at 30% in the US and these values may under report the true prevalence of people who experience long term pain as additional research has shown that 73% will have a reoccurrence of symptoms within 12 months of the original injury indicating that while the pain and symptoms may resolve, additional impairments or issues may underlie the symptoms. Biopsychosocial factors such as depression, post traumatic stress, anxiety, pain catastrophizing, and negative emotions have been closely linked to pain and can influence a patient's pain perceptions. Along these lines, the memory of past experiences and trauma potentially play a large role in these biopsychosocial responses. Research is evolving and a strong correlation has been established between chronic pain and prior history of trauma or abuse and also non-traumatic incidents such as motor vehicle accidents and injuries/surgical procedures. This has led to speculation and research that explores how a variety of life events may become stimulants for long-term alterations in the processing and manifestation of pain and how they may have an enduring impact on physical health outcomes. The proposed research will add to the body of knowledge underlying the association between pain, memory, autonomic system, and neuromuscular function. The goal of this project is to study the relationship between pain memory systems, specifically acute pain, short-term memory of pain, and long term pain memory, and their effects upon neuromuscular and autonomic system responses in the body.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~data will be collected in one, one hour session. during the session, hhd will be collected during or immediately following intervention or condition
This trial's timeline: 3 weeks for screening, Varies for treatment, and data will be collected in one, one hour session. during the session, hhd will be collected during or immediately following intervention or condition for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in hand held dynamometric (HHD) measures from baseline to either during or immediately post intervention or condition
Change in heart rate variability (HRV) from baseline to either during or immediately post intervention or condition
Change in pressure pain threshold (PPT) from baseline to either during or immediately post intervention or condition
+1 more
Secondary outcome measures
Change in verbal numeric pain scale (NPS) rating from baseline to immediately post intervention or condition

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: History of Significant InjuryActive Control4 Interventions
Experimental Noxious Stimulus, Memory of Experimental Noxious Stimulus, Memory of Prior Significant Injury, Mental Challenge Test
Group II: No History of Significant InjuryPlacebo Group4 Interventions
Experimental Noxious Stimulus, Memory of Experimental Noxious Stimulus, Memory of Prior Significant Injury, Mental Challenge Test

Find a Location

Who is running the clinical trial?

Mount St. Mary's College, Los Angeles, CALead Sponsor
2 Previous Clinical Trials
135 Total Patients Enrolled
M. Samuel Cheng, DScStudy ChairNova Southeastern University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~5 spots leftby Apr 2025