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Corticosteroid

Methylprednisolone taper for Total Knee Replacement

Phase 4
Waitlist Available
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre treatment
Awards & highlights

Study Summary

This trial will evaluate whether or not a methylprednisolone taper can improve range of motion or delayed recovery in patients six weeks to three months post-TKA.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Range of Motion in Degrees at Pre and Post Treatment
Secondary outcome measures
Adverse Events or Outcomes Outside of Manipulations Under Anesthesia
Number of Participants With Complications Following Treatment
Patient Reported Outcome Measures: Overall Assessment of Knee 6 Weeks After Treatment
+8 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Methylprednisolone taperActive Control1 Intervention
21 x 4mg tablets at 6 weeks, qualifying for MUA if ROM <90° at 8 weeks
Group II: Placebo taperPlacebo Group1 Intervention
21 sugar tablets at 6 weeks with standard management, qualifying for MUA if ROM <90° at 8 weeks

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
422 Previous Clinical Trials
163,527 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What medical conditions typically necessitate Methylprednisolone tapering?

"For ophthalmia, sympathetic the most efficacious treatment tends to be a Methylprednisolone taper. This same medication is also beneficial for managing scalp structure, temporal arteritis and lupus erythematosus."

Answered by AI

Are there vacancies in this research trial for participants?

"Affirmative. The clinical trial registry on clincialtrials.gov indicates that this study is recruiting participants and was first announced on March 3rd 2022, with the most recent update made April 26th of this year. 112 individuals are required to be recruited from one site."

Answered by AI

Could you provide insight into the potential hazards associated with a Methylprednisolone taper regimen?

"There is a body of evidence in favour of Methylprednisolone taper, so it has been allocated a score of 3."

Answered by AI

How many individuals are currently enrolled in this research endeavor?

"Affirmative. According to records available on clinicaltrials.gov, this medical experiment was initially posted on March 3rd 2022 and is currently recruiting participants. This initiative requires 112 patients from a single site to be enrolled."

Answered by AI

Has research been conducted to explore the efficacy of a Methylprednisolone taper?

"At this time, there are 150 studies on Methylprednisolone taper. Of these trials, 39 have reached Phase 3. While the majority of research is based in Houston, Texas; 6845 sites worldwide are participating in related clinical investigations."

Answered by AI
Recent research and studies
Osteoarthritis and CartilageJournal
Projected Increase in Total Knee Arthroplasty in the United States – an Alternative Projection Model
Inacio, M.C.S., E.W. Paxton, S.E. Graves, R.S. Namba, and S. Nemes. 2017. “Projected Increase in Total Knee Arthroplasty in the United States – an Alternative Projection Model”. Osteoarthritis and Cartilage. Elsevier BV. doi:10.1016/j.joca.2017.07.022.
The Journal of ArthroplastyJournal
Patient Outcomes Following Unicompartmental or Bicompartmental Knee Arthroplasty
Callahan, Christopher M., Brenda G. Drake, David A. Heck, and Robert S. Dittus. 1995. “Patient Outcomes Following Unicompartmental or Bicompartmental Knee Arthroplasty”. The Journal of Arthroplasty. Elsevier BV. doi:10.1016/s0883-5403(05)80120-2.
Acta OrthopaedicaJournal
Perioperative Adjuvant Corticosteroids for Postoperative Analgesia in Knee Arthroplasty
Mohammad, Hasan R, Thomas W Hamilton, Louise Strickland, Marialena Trivella, David Murray, and Hemant Pandit. 2017. “Perioperative Adjuvant Corticosteroids for Postoperative Analgesia in Knee Arthroplasty”. Acta Orthopaedica. Medical Journals Sweden AB. doi:10.1080/17453674.2017.1391409.
The Journal of ArthroplastyJournal
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study
Xu, Hong, Shaoyun Zhang, Jinwei Xie, Yiting Lei, Guorui Cao, and Fuxing Pei. 2018. “Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study”. The Journal of Arthroplasty. Elsevier BV. doi:10.1016/j.arth.2018.06.031.
~1 spots leftby Apr 2025
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