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Prostaglandin E1 Analog

Misoprostol for Labor Induction

Phase 4
Waitlist Available
Led By Jaimey Pauli, MD
Research Sponsored by Milton S. Hershey Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from start of induction of labor (first misoprostol administration) to initiation of oxytocin for labor augmentation, up to 36 hours
Awards & highlights

Study Summary

This study is evaluating whether misoprostol administered orally is at least as effective as misoprostol administered vaginally for cervical ripening and the induction of labor.

Eligible Conditions
  • Labor Induction
  • Pregnancy

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from start of induction of labor (first misoprostol administration) to initiation of oxytocin for labor augmentation, up to 36 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and from start of induction of labor (first misoprostol administration) to initiation of oxytocin for labor augmentation, up to 36 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time to Active Labor
Secondary outcome measures
Cesarean section
Morbidity - disease rate
Rate of Abandoning Misoprostol for Cervical Ripening and Switching to Mechanical Dilation for Cervical Ripening
+9 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Oral misoprostolExperimental Treatment1 Intervention
oral misoprostol given 25 mcg every 2 hours
Group II: Vaginal misoprostolActive Control1 Intervention
vaginal misoprostol given 25 mcg every 4 hours
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Misoprostol
2008
Completed Phase 4
~3340

Find a Location

Who is running the clinical trial?

Milton S. Hershey Medical CenterLead Sponsor
492 Previous Clinical Trials
2,798,788 Total Patients Enrolled
Jaimey Pauli, MDPrincipal InvestigatorMilton S. Hershey Medical Center
1 Previous Clinical Trials

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor
Jaimey M. Pauli, MD 2017. "A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02777190.
~5 spots leftby Apr 2025
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