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Corticosteroid

Experimental for Torn Meniscus (SLAM Trial)

Phase 2
Waitlist Available
Research Sponsored by Austin V Stone
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 4 months, 1 year, 2 years
Awards & highlights

SLAM Trial Summary

This trial will study if a certain medication can help prevent changes in bone shape after ACL surgery.

Eligible Conditions
  • Torn Meniscus
  • Anterior Cruciate Ligament Tear

SLAM Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 4 months, 1 year, 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 4 months, 1 year, 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Bone Shape (Baseline to 4 Months)
Secondary outcome measures
Change in CTXII (Baseline to 4 Months)
Change in ICOAP (Baseline to 1 Year)
Change in ICOAP (Baseline to 2 Years)
+7 more

Side effects data

From 2021 Phase 4 trial • 70 Patients • NCT03895840
11%
Fall
10%
arthralgia
6%
URI
4%
Bruising
3%
headache
3%
Swelling
1%
Hyperglycemia
1%
Epistaxis
1%
Hematuria
1%
Flu-like symptoms
1%
Rhinorrea
1%
Otitis media
1%
Blister
1%
Allergic rhinitis
100%
80%
60%
40%
20%
0%
Study treatment Arm
Intra-articular Zilretta Injection

SLAM Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ExperimentalExperimental Treatment1 Intervention
The experimental group will receive a single 32 mg Zilretta injection approximately 8 weeks after meniscus surgery.
Group II: PlaceboPlacebo Group1 Intervention
The placebo group will receive a single 5 mL injection of normal saline approximately 8 weeks after meniscus surgery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Zilretta
2018
Completed Phase 4
~70

Find a Location

Who is running the clinical trial?

Austin V StoneLead Sponsor
4 Previous Clinical Trials
73 Total Patients Enrolled
Austin Stone, MD, PhDStudy DirectorUniversity of Kentucky
3 Previous Clinical Trials
68 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Success of Long-acting Anti-inflammatories After Anterior Cruciate Ligament and Meniscal Injury
Austin V Stone 2020. "Success of Long-acting Anti-inflammatories After Anterior Cruciate Ligament and Meniscal Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04331002.
~0 spots leftby Apr 2025
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