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Antipsychotic

Combination Therapy for Cyclic Vomiting Syndrome

Phase 2
Waitlist Available
Research Sponsored by Spectrum Health - Lakeland
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
adult patients with clinical diagnosis of cyclic vomiting in the ED
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2, 24, 48 hours
Awards & highlights

Study Summary

This trial will compare two drugs to see which is better at treating cyclic vomiting with fewer side effects.

Eligible Conditions
  • Cyclic Vomiting Syndrome

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are an adult patient who has been diagnosed with cyclic vomiting in the emergency department.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at discharge from ed
This trial's timeline: 3 weeks for screening, Varies for treatment, and at discharge from ed for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
abdominal pain
nausea
Secondary outcome measures
Discharge in 2 hours
Prolonged ED length of stay over 4 hours
Rescue anti-emetics in Emergency Department (ED)
+3 more

Trial Design

3Treatment groups
Active Control
Group I: haloperidolActive Control1 Intervention
these patients will receive 5mg IM haloperidol
Group II: ondansetronActive Control1 Intervention
these patients will receive 8mg IV ondansetron
Group III: droperidolActive Control1 Intervention
these patients will receive 2.5mg IV droperidol

Find a Location

Who is running the clinical trial?

Spectrum Health - LakelandLead Sponsor
12 Previous Clinical Trials
1,761 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical trial admit participants who are in the senior age bracket?

"As per the guidelines listed for this trial, individuals aged 18 to 65 are eligible for enrollment."

Answered by AI

Could you provide a synopsis of the other exploratory research conducted on haloperidol?

"Presently, there are 9 clinical trials in progress related to haloperidol. Of these studies, 3 have progressed into Phase 3 and are being conducted at 51 locations centered around Saint Joseph, Michigan."

Answered by AI

What aims are being pursued in this clinical exploration?

"This trial is primarily tracking how well the treatment works to reduce nausea at two, twenty-four and forty-eight hours. Secondary endpoints of interest include the proportion of patients who are issued discharge orders in 2 hours, differences in abdominal pain scores relative to baseline at 1,2 24 and 48 hours, as well as assessing when rescue narcotics become necessary within the emergency department."

Answered by AI

What clinical conditions is haloperidol frequently prescribed for?

"Haloperidol is often employed to assuage nausea, as well as address agitation, hyperactivity and hostile reactions."

Answered by AI

What is the participant count for this experiment?

"Yes, the listings on clinicaltrials.gov confirm that this medical trial is recruiting participants as of October 25th 2022. It was initially posted August 30th 2021 and seeks to enrol 100 subjects across a single location."

Answered by AI

What possible health risks are associated with the use of haloperidol?

"Haloperidol's safety is rated a 2 on the scale, as there exists some evidence of its security but no proof for effectiveness in this Phase 2 trial."

Answered by AI

Who qualifies to join this medical experiment?

"To be eligible for this research, individuals must have experienced vomiting and lie within the age group of 18 - 65. The trial is seeking to enrol approximately one hundred participants in total."

Answered by AI

Are additional participants being sought for this experiment?

"According to clinicaltrials.gov, the recruitment of patients for this medical trial is still ongoing since it was first made available on August 30th 2021 and updated lastly in October 25th 2022."

Answered by AI

Who else is applying?

What state do they live in?
District of Columbia
What site did they apply to?
Lakeland Regional Healthcare
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
3+
~11 spots leftby Apr 2025