Your session is about to expire
← Back to Search
Sling vs Botox for Urinary Incontinence (MUSA Trial)
MUSA Trial Summary
This trial is testing whether Botox or a mid-urethral sling is more effective in treating MUI symptoms.
MUSA Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowMUSA Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.MUSA Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- You have cancer in your pelvic organs that is currently growing.You are younger than 21 years old.You are scheduled to have surgery for a certain type of prolapse in the vaginal area.Women who have had Botox injected into their bladder in the past year.Women who are having their uterus removed for any reason.You have been diagnosed with stress urinary incontinence (SUI) based on a positive cough stress test or urodynamic evaluation within the past 18 months.You have a serious spinal cord injury or advanced neurological conditions like Multiple Sclerosis, Parkinson's, Myasthenia Gravis, or Charcot-Marie-Tooth disease.You are unable to walk.You have been diagnosed with or have a history of bladder pain or chronic pelvic pain.Women who have had surgery to fix a certain type of pelvic organ prolapse in the last 6 months.You report feeling bothered by leaking urine when you feel the need to go urgently.You have a certain type of pelvic organ prolapse that extends beyond a specific point, even if you don't have symptoms.You have had trouble emptying your bladder completely, or you are currently using a catheter.You have not been checked for blood in your urine.You feel bothered by urine leakage when you do physical activities, cough, or sneeze.You have had surgery for urinary incontinence or prolapse using certain types of materials.You have urinary urgency and frequency based on a bladder diary.You have been experiencing urinary symptoms for more than 3 months.You still have symptoms even after trying different treatments recommended by your doctor.You have not responded well to oral medications for overactive bladder, unless you cannot tolerate them or your doctor says you shouldn't take them.You have had a test to check your bladder function in the past 18 months.
- Group 1: Botox A® injection
- Group 2: Mid-urethral sling
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
At how many different hospitals is this medical study being run today?
"Currently, there are 8 active sites for this trial; however, the locations of these centres (e.g. Birmingham, Providence, Philadelphia) may be far from where potential patients live. It is worth considering enrolling at a site that is close to your residences to limit travel difficulty and demands."
How many people have signed up for this research project?
"That is correct. The clinical trial was originally posted on 6/8/2020 and is still recruiting patients. Last edited on 8/10/2022, the study needs a total of 146 subjects from 8 different sites."
Are there many published papers on Botox A® injection?
"Botox A® was first trialled in 2012 at Rothman Institute. As of now, 459 clinical trials have completed with Botox A®, 68 of which are still recruiting patients. Many of these active studies are based in Birmingham, Alabama."
Has the FDA okayed Botox A® as a therapeutic injection?
"There is some clinical data supporting Botox A®'s efficacy and multiple rounds of safety trials have been completed, so it received a score of 3."
What are patients most often using Botox A® injections for?
"Botox A® injection is most often used to treat urinary incontinence. Other potential conditions that this medication can help alleviate include spinal cord, botox, and overactive bladder syndrome (oabs)."
Are people still able to sign up for this experiment?
"The trial is still active and presently looking for participants. According to the information found on clinicaltrials.gov, the trial was originally posted on 6/8/2020, with the most recent edit taking place on 8/10/2022."
Share this study with friends
Copy Link
Messenger