HindSight for Severe Sepsis

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Baystate Health, Springfield, MA
Severe Sepsis+3 More
HindSight - Other
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

Machine Learning Sepsis Alert Notification Using Clinical Data

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Eligible Conditions

  • Severe Sepsis
  • Septic Shock
  • Pyemia

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Severe Sepsis

Study Objectives

This trial is evaluating whether HindSight will improve 2 primary outcomes in patients with Severe Sepsis. Measurement will happen over the course of Through study completion, an average of eleven months.

Through study completion, an average of eleven months
False alert reduction
Through study completion, human subjects involvement will occur for an average of eight months
Rate of reduction in false alerts

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Other trials for Severe Sepsis

Trial Design

2 Treatment Groups

Control
1 of 2
Experimental
1 of 2
Active Control
Experimental Treatment

This trial requires 37986 total participants across 2 different treatment groups

This trial involves 2 different treatments. HindSight is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Experimental
Other
The experimental arm will involve patients monitored by HindSight.
Control
Other
The control arm will involve patients monitored by InSight.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: through study completion, human subjects involvement will occur for an average of eight months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly through study completion, human subjects involvement will occur for an average of eight months for reporting.

Closest Location

Baystate Health - Springfield, MA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
During the study period, all patients over the age of 18 presenting to the emergency department or admitted to an inpatient unit at the participating facilities will automatically be enrolled in the study, until the enrollment target for the study is met

Patient Q&A Section

Can pyemia be cured?

"Findings from a recent study, pyemic patients showed significant improvement, although it was not statistically significant. The findings of this study suggest that in all patients with pyemic fever, the diagnosis should be considered even if the level of inflammatory markers is normal." - Anonymous Online Contributor

Unverified Answer

What are the signs of pyemia?

"Pyemia can be characterized by elevated white blood cell count and positive peripheral blood smear. The presence of septicemia should generate suspicion and should be confirmed by blood culture after peripheral venous catheter insertion." - Anonymous Online Contributor

Unverified Answer

What are common treatments for pyemia?

"These data can serve as a guideline to the pathologist when assessing the cause of an acutely febriate patient who presents with pyuria. One can also guide patient treatment at the bedside with the clinician to consider the cause of pyuria." - Anonymous Online Contributor

Unverified Answer

How many people get pyemia a year in the United States?

"Pyemic disease is a major cause of death among US adults and is a top killer of children. However, due to its low rate of diagnoses, there is scant evidence on whether pyemic disease affects the overall public health burden. The study data, if estimates from the National Center for Health Statistics can be relied upon, suggest that pyemic disease affects the overall public health burden, as demonstrated in the increase in mortality rates during the mid-1980s. The study data, if estimates from the National Center for Health Statistics can be relied upon, suggest that pyemic illness has a considerable public health burden and warrants further study." - Anonymous Online Contributor

Unverified Answer

What is pyemia?

"The data presented in this study show that the prevalence of pyemias is extremely high among patients with chronic kidney disease and, by implication, in the dialysis population." - Anonymous Online Contributor

Unverified Answer

What causes pyemia?

"Inappropriate use of antibiotics for upper infections is common, especially among hospitalized patients. Many are empirically begun in the clinical setting on the basis of clinical judgment without careful documentation and evaluation of the cultures for suspicion of infection by the responsible physicians. When considering initiating empiric antibiotic therapy, clinical judgment combined with cultures and physical examination are most useful in predicting the need for antibiotics in a particular patient. The empirical antibiotic therapy should be discontinued based on negative cultures and clinical resolution of symptoms related to the infection. These patients should be follow-up regularly, ideally in an outpatient setting to allow documentation of clinical signs and laboratory data before and after antibiotic therapy has been stopped and to evaluate for recurrence of pyemia." - Anonymous Online Contributor

Unverified Answer

What does hindsight usually treat?

"A great deal of the controversy over the treatment of febrile neutropenia, which is a common and potentially devastating complication of chemotherapy, hinges on the question of whether febrile neutropenia can be predicted and prevented. If a prospective randomized trial shows febrile neutropenia to be a marker of adverse outcome, then clinical trials should study prevention, not treatment, because prophylactic treatment would have to be targeted at an extremely ill and potentially fatal subset of patients." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of pyemia?

"Primary pyemia is a well-described cause of thrombotic PE, which is not a common cause of embolism in general. It is a cause of PE in patients on antimicrobials, with recent history of recent trauma or surgery, and also has the reputation of being a cause of the disseminated intravascular coagulation syndrome (DIC) as the disseminated intravascular coagulation (DIC) has been seen in some cases of primary PE." - Anonymous Online Contributor

Unverified Answer

Does hindsight improve quality of life for those with pyemia?

"For patients with pyemia, the retrospective diagnosis of pyemia significantly improved quality of life. However, a retrospective diagnosis of pyemia does not seem to change the rate of treatment failure and therefore should not be used for the management of symptomatic patients. Further prospective studies are needed to validate our findings." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets pyemia?

"Approximately 60% of pyemias occur in children 12 years and younger, yet the [incidence of pyemias] in children less than 5 years old and in adults is significantly higher (20% and 30%, respectively). If a person is less than 5 years old when they contract the disease, they have a higher chance of survival. People who are 65 years old and older are less likely to have a successful outcome if they contract pyemia, but because pyemia occurs more commonly in women over 65 years old it can be important for them to be screened. Treatment for pyemias in children is similar to that for pyemias in adults." - Anonymous Online Contributor

Unverified Answer

Has hindsight proven to be more effective than a placebo?

"A one month course of antibiotics in patients with acute pyelonephritis decreased the risk of nephrolithiasis in those treated with antibiotics, or a placebo and in patients not treated with antibiotic therapy. A recent study showing long term outcome in patients with pyelonephritis of short duration compared antibiotic treatment to a placebo treatment in all cases. A recent small study of patients with pyelonephritis, shows the benefit of antibiotic therapy. The benefit of antibiotic treatment in acute pyelonephritis is minimal to negligible but seems to affect the short term outcome in children and may be useful in adults when other alternatives are considered for treatment of pyelonephritis in the presence of co-morbidities or risks." - Anonymous Online Contributor

Unverified Answer

What is the latest research for pyemia?

"More recent trials and meta-analyses have helped to establish the usefulness of the antibiotic regimen for pyemia. For patients, decisions regarding antimicrobial therapy should be tailored to the pathogen(s) involved and the availability of an appropriate and comprehensive approach to patient care. The risk of failure and adverse events should be balanced against the risk of persistence of infection with minimal antibacterial therapy." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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