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Enalapril for Endovascular Thrombectomy (DETECT Trial)

Phase 2
Waitlist Available
Led By Aristeidis H Katsanos, MD
Research Sponsored by Hamilton Health Sciences Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 18 months
Awards & highlights

DETECT Trial Summary

This trial is testing whether intensive blood pressure control immediately after successful endovascular stroke thrombectomy can improve patient outcomes.

Eligible Conditions
  • Mechanical Thrombectomy
  • Endovascular Thrombectomy
  • Vascular Occlusion
  • Stroke
  • High Blood Pressure

DETECT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean enrollment rate.
Number of participants with treatment allocation change.
Secondary outcome measures
Absolute difference in flow velocity measurements in transcranial Doppler.
Absolute difference in the NIH Stroke Scale change at day 1.
Absolute difference in the NIH Stroke Scale change at day 2.
+1 more
Other outcome measures
Absolute difference in final infarct volumes.
Absolute difference in hospital stay.
Absolute difference in mean systolic blood pressure values.
+9 more

DETECT Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Intensive Blood Pressure managementExperimental Treatment3 Interventions
Participants assigned to the intensive blood pressure management arm will be treated using approved antihypertensive medications to have systolic blood pressure readings under 140 mmHg for the first 48 hours after enrollment into the study.
Group II: Standard Blood Pressure managementActive Control3 Interventions
Participants assigned to the standard blood pressure management arm will be treated using approved antihypertensive medications to have systolic blood pressure readings under 180 mmHg for the first 48 hours after enrollment into the study.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hydralazine
2020
Completed Phase 4
~940
Enalapril
2016
Completed Phase 4
~13690
Labetalol
2020
Completed Phase 4
~2490

Find a Location

Who is running the clinical trial?

Hamilton Health Sciences CorporationLead Sponsor
368 Previous Clinical Trials
300,963 Total Patients Enrolled
Aristeidis H Katsanos, MDPrincipal InvestigatorHamilton General Hospital, Hamilton Health Sciences

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the goals that researchers are hoping to achieve with this clinical trial?

"The primary goal of this research, which will be overseen until its conclusion (around 18 months), is to evaluate the number of participants that need their treatment allocation changed. Additionally, investigators will also look at secondary outcomes such as the number of patients with any intracranial hemorrhage (as identified on a follow-up CT scan) and the absolute difference in flow velocity measurements in transcranial Doppler examination. Lastly, researchers will compare the NIH Stroke Scale scores from day 2 to see if there is a significant difference."

Answered by AI

Are patients being recruited for this clinical trial at this time?

"Yes, that is correct. The clinical trial is currently looking for 30 individuals to enroll at 1 site. According to the information available on clinicaltrials.gov, the study was originally posted on 10/23/2020 and updated as recently as 3/21/2022."

Answered by AI

What are some other studies that have used Enalapril as an active ingredient?

"Enalapril is being researched in 24 different ongoing clinical trials, 7 of which are Phase 3. The majority of these studies originate from Dayton, Ohio; however, there are 508 total locations for Enalapril clinical trials."

Answered by AI

For what ailments is Enalapril regularly prescribed?

"Enalapril is commonly used to manage hypertension, but can also be effective in treating other cardiovascular conditions such as chronic stable angina pectoris, symptomatic congestive heart failure, and hypertensive emergency."

Answered by AI

How many test subjects are in this clinical trial?

"That is correct. The clinicaltrials.gov website has information indicating that this trial is looking for enrollees. This research project was originally posted on October 23rd 2020 and updated most recently on March 21st 2022. There is a need for 30 individuals at a single site."

Answered by AI

Are there any harmful side effects to Enalapril?

"Enalapril's safety was given a score of 2 out of 3 by our Power team. This is because, although there is some data supporting Enalapril's safety, there is no evidence yet that it is an effective medication."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Blood Pressure Management in Stroke Following Endovascular Treatment
2020. "Blood Pressure Management in Stroke Following Endovascular Treatment". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04484350.
~7 spots leftby Apr 2025
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