All > Blood Pressure

Enalapril for High Blood Pressure

Hamilton General Hospital, Hamilton, Canada
High Blood Pressure+4 More ConditionsEnalapril - Drug
Eligibility
18+
All Sexes

Study Summary

This trial is testing whether intensive blood pressure control immediately after successful endovascular stroke thrombectomy can improve patient outcomes.

Eligible Conditions
  • High Blood Pressure
  • Vascular Occlusion
  • Endovascular Thrombectomy
  • Mechanical Thrombectomy
  • Stroke

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 2

Similar Trials

1
Standard of care
2
Risk Factor Management
1
labetalol/hydralazine/enalapril

Study Objectives

2 Primary · 4 Secondary · Reporting Duration: through study completion, an average of 18 months

Hour 18
Absolute difference in flow velocity measurements in transcranial Doppler.
Hour 24
Number of participants with neurological deterioration.
Hour 12
Absolute difference in the NIH Stroke Scale change at day 1.
Absolute difference in the decline of the Alberta stroke program early CT scores.
Number of participants with any intracranial hemorrhage.
Number of participants with symptomatic intracranial hemorrhage.
Hour 48
Absolute difference in mean systolic blood pressure values.
Number of participants with treatment allocation change.
Hour 12
Absolute difference in the NIH Stroke Scale change at day 2.
Day 7
Absolute difference in final infarct volumes.
Day 7
Absolute difference in hospital stay.
Functional outcome during hospitalization.
Number of deaths during hospitalization.
Number of participants with favorable functional outcomes during hospitalization.
Day 90
Functional outcome during follow-up.
Number of deaths during follow-up.
Number of participants with favorable functional outcomes during follow-up
Month 18
Mean enrollment rate.

Trial Safety

Phase-Based Safety

2 of 3
This is further along than 68% of similar trials

Similar Trials

1
Standard of care
3
Risk Factor Management
2
labetalol/hydralazine/enalapril

Awards & Highlights

Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
No Placebo Group
All patients enrolled in this trial will receive the new treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2 Treatment Groups

Standard Blood Pressure management
1 of 2
Intensive Blood Pressure management
1 of 2

Active Control

Experimental Treatment

30 Total Participants · 2 Treatment Groups

Primary Treatment: Enalapril · No Placebo Group · Phase 2

Intensive Blood Pressure managementExperimental Group · 3 Interventions: Hydralazine, Enalapril, Labetalol · Intervention Types: Drug, Drug, Drug
Standard Blood Pressure managementActiveComparator Group · 3 Interventions: Hydralazine, Enalapril, Labetalol · Intervention Types: Drug, Drug, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hydralazine
FDA approved
Enalapril
FDA approved
Labetalol
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: through study completion, an average of 18 months

Who is running the clinical trial?

Hamilton Health Sciences CorporationLead Sponsor
351 Previous Clinical Trials
275,470 Total Patients Enrolled
Aristeidis H Katsanos, MDPrincipal InvestigatorHamilton General Hospital, Hamilton Health Sciences

Eligibility Criteria

Age 18+ · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You can receive endovascular treatment within 24 hours of experiencing symptoms, as determined by current medical guidelines.
References

Frequently Asked Questions

What are the goals that researchers are hoping to achieve with this clinical trial?

"The primary goal of this research, which will be overseen until its conclusion (around 18 months), is to evaluate the number of participants that need their treatment allocation changed. Additionally, investigators will also look at secondary outcomes such as the number of patients with any intracranial hemorrhage (as identified on a follow-up CT scan) and the absolute difference in flow velocity measurements in transcranial Doppler examination. Lastly, researchers will compare the NIH Stroke Scale scores from day 2 to see if there is a significant difference." - Anonymous Online Contributor

Unverified Answer

Are patients being recruited for this clinical trial at this time?

"Yes, that is correct. The clinical trial is currently looking for 30 individuals to enroll at 1 site. According to the information available on clinicaltrials.gov, the study was originally posted on 10/23/2020 and updated as recently as 3/21/2022." - Anonymous Online Contributor

Unverified Answer

What are some other studies that have used Enalapril as an active ingredient?

"Enalapril is being researched in 24 different ongoing clinical trials, 7 of which are Phase 3. The majority of these studies originate from Dayton, Ohio; however, there are 508 total locations for Enalapril clinical trials." - Anonymous Online Contributor

Unverified Answer

For what ailments is Enalapril regularly prescribed?

"Enalapril is commonly used to manage hypertension, but can also be effective in treating other cardiovascular conditions such as chronic stable angina pectoris, symptomatic congestive heart failure, and hypertensive emergency." - Anonymous Online Contributor

Unverified Answer

How many test subjects are in this clinical trial?

"That is correct. The clinicaltrials.gov website has information indicating that this trial is looking for enrollees. This research project was originally posted on October 23rd 2020 and updated most recently on March 21st 2022. There is a need for 30 individuals at a single site." - Anonymous Online Contributor

Unverified Answer

Are there any harmful side effects to Enalapril?

"Enalapril's safety was given a score of 2 out of 3 by our Power team. This is because, although there is some data supporting Enalapril's safety, there is no evidence yet that it is an effective medication." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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