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BNC210 for Post-Traumatic Stress Disorder (ATTUNE Trial)

Phase 2
Waitlist Available
Research Sponsored by Bionomics Limited
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

ATTUNE Trial Summary

This trial will test whether the drug BNC210 is better than placebo at reducing symptoms of post-traumatic stress disorder (PTSD).

Eligible Conditions
  • Post Traumatic Stress Disorder

ATTUNE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Clinician Administered PTSD Scale for DSM-5 (CAPS-5)
Clinician Global Impression (CGI)
Hamilton Anxiety Rating Scale (HAM-A)
+5 more

Side effects data

From 2018 Phase 2 trial • 193 Patients • NCT02933606
8%
Upper Respiratory Tract Infection
8%
Diarrhoea
8%
Nausea
8%
Nasopharyngitis
6%
Headache
6%
Somnolence
6%
Dry Mouth
4%
Dizziness
4%
Fatigue
2%
Dyspepsia
2%
Viral Infection
100%
80%
60%
40%
20%
0%
Study treatment Arm
BNC210 600 mg b.i.d.
BNC210 300 mg b.i.d.
BNC210 150 mg b.i.d.
Placebo b.i.d.

ATTUNE Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: BNC210Experimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
BNC210
2016
Completed Phase 2
~450

Find a Location

Who is running the clinical trial?

Bionomics LimitedLead Sponsor
6 Previous Clinical Trials
558 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the age restriction for this trial extend beyond 85 years?

"This clinical trial is seeking participants who are over the legal age of consent but not yet 75 years old."

Answered by AI

To what extent can BNC210 be deemed hazardous to patients?

"Our team at Power assessed BNC210's safety level to be a 2 as this is a Phase 2 trial and while there are some data points supporting its safeness, no studies have yet confirmed efficacy."

Answered by AI

Are there any vacancies remaining in this trial for participants?

"Affirmative. The clinical trial data hosted on clinicaltrials.gov reveals that this medical experiment is actively seeking enrollees, which was initially published on July 27th 2021 and most recently updated September 1st 2022. Ultimately, 200 patients need to be recruited from 28 distinct sites."

Answered by AI

Are there multiple sites in Canada conducting this research experiment?

"Currently, 28 sites around the US are enrolling participants in this trial. These locations span from Beverly Hills to Cherry Hill and Colton, as well as other cities. For convenience sake, it is advantageous to select a clinic nearby so that commuting does not become an issue for those who choose to take part."

Answered by AI

Is it feasible for me to partake in this research?

"This clinical trial is targeting 200 individuals aged between 18 and 75 who have been diagnosed with stress or trauma-related disorders. In order to join the study, patients must meet specific criteria such as a CAPS-5 Total Symptom Severity Score of ≥30 at Screening and Baseline, no >25% decrease in score from screening to baseline, and ability to swallow tablets."

Answered by AI

What is the overall enrollment rate of this medical study?

"Affirmative. According to the clinicaltrials.gov webpage, this medical trial opened on July 27th 2021 and is still actively recruiting as of September 1st 2022. The goal is to admit two hundred patients from 28 different sites."

Answered by AI

Who else is applying?

What state do they live in?
Nebraska
Other
Florida
Texas
How old are they?
18 - 65
What site did they apply to?
ATTUNE Study Clinical Trial Site
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
1
3+

Why did patients apply to this trial?

How responsive is this trial?

Typically responds via
Email
Recent research and studies
clinicaltrials.govStudy
A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD)
2021. "A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04951076.
~58 spots leftby Apr 2025
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