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Nitrous Oxide for Post-Traumatic Stress Disorder (N2OP Trial)

Phase 2
Waitlist Available
Led By Carolyn I Rodriguez, MD PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 week
Awards & highlights

N2OP Trial Summary

This trial will test whether nitrous oxide can help Veterans with PTSD by reducing their symptoms within 1 day, with limited side effects.

Eligible Conditions
  • Post-Traumatic Stress Disorder

N2OP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Improvement in the Severity of PTSD as Measured by the Clinician Administered PTSD Scale DSM5 (CAPS-5)

N2OP Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Nitrous OxideExperimental Treatment3 Interventions
PTSD participants in this arm will receive and admixture of up to 50%nitrous oxide and 50% oxygen plus intravenous saline
Group II: MidazolamActive Control3 Interventions
PTSD participants in this arm will receive and admixture of up to 50%nitrogen and 50% oxygen plus intravenous 0.045mg/kg midazolam
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nitrous Oxide
2016
Completed Phase 4
~8230
Saline
2013
Completed Phase 4
~1050
Oxygen
2013
Completed Phase 4
~12430

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,608 Previous Clinical Trials
3,306,531 Total Patients Enrolled
Carolyn I Rodriguez, MD PhDPrincipal InvestigatorVA Palo Alto Health Care System, Palo Alto, CA

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Nitrous Oxide for PTSD
2021. "Nitrous Oxide for PTSD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04378426.
~0 spots leftby Apr 2025
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