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Chemotherapy for Gastric Cancer
Study Summary
This trial will study if it is safe to give patients with stomach or gastroesophageal junction cancer who have not had prior treatment irinotecan, trifluridine/tipiracil, and oxaliplatin.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- My stomach cancer is advanced but hasn't been treated with systemic therapy yet.I do not have an ongoing infection that is getting worse despite treatment.I am fully active or can carry out light work.I have had bowel blockage or fluid buildup in my abdomen due to cancer spread.I have moderate to severe nerve damage from any cause.I do not have hepatitis B or C, HIV, and am not on drugs that weaken my immune system.I am able to understand and agree to the treatment plan.I am using or willing to use effective birth control or practice abstinence during and 6 months after the study.My blood, kidney, and liver tests meet the required levels for the trial.You have had an allergic reaction to the medications that will be used in the study.I am 18 years old or older.I have had radiation therapy to my pelvis or a significant part of my bone marrow.I have a history of lung scarring or fibrosis.I have had chemotherapy for advanced stomach or GEJ cancer.I have had cancer before, but it was either non-melanoma skin cancer, cervical, uterine, or low-grade prostate cancer treated over 6 months ago or any type treated over 5 years ago and considered cured.I haven't had a serious illness like a heart attack or uncontrolled diabetes in the last 6 months.I have a history of connective tissue disorders like lupus.I am not pregnant or breastfeeding, and if capable of childbearing, I have a recent negative pregnancy test and use effective contraception.My blood protein levels dropped by 20% or more recently.I am currently taking Coumadin.I am not breastfeeding or will stop before starting the treatment.I can follow the study's schedule and requirements without any issues.I do not have unstable brain metastases.My cancer is HER2 positive, or was found to be after joining the study.I had palliative radiotherapy over 4 weeks ago and have recovered from its side effects.I am a woman who can have children and have a negative pregnancy test.I agree not to donate sperm during and for 6 months after the study.I had surgery over 4 weeks ago and have recovered from its side effects.I have treated brain metastasis, am stable on steroids or off them, and my brain scans have been stable for 3 months.I completed my initial cancer treatment over 6 months ago.My cancer's HER2 status is either not tested, negative, or unknown.
- Group 1: Single Arm iTTO treatment
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
To what extent is this medical experiment being utilized by volunteers?
"Unfortunately, this trial has ceased searching for new participants; the initial posting date was August 31st 2021 and it was last updated on March 18th 2021. However, those interested in alternative trials can find 1177 studies actively looking for patients with stomach cancer and 538 research projects recruiting individuals to receive irinotecan."
In what other contexts has Irinotecan been examined through medical research?
"Currently, there are 538 ongoing trials that involve Irinotecan with 156 of them in the last phase. While Woolloongabba, Queensland has a high concentration of these research projects, this drug is being studied at 19494 distinct sites worldwide."
What kind of adverse effects has Irinotecan been linked to?
"The safety of Irinotecan is provisionally assessed at a score of 2, being that the drug has been through Phase 2 trials with evidence backing its security but not yet affirming its effectiveness."
Are there any vacancies available for this research project?
"This medical trial is no longer recruiting, as the last update to its information was made on March 18th 2021. If you are searching for other studies related to stomach cancer and Irinotecan, there are currently 1177 and 538 trials respectively that are actively enrolling participants."
What pathologies is Irinotecan commonly prescribed to address?
"Irinotecan is frequently prescribed to patients who have already used oxaliplatin chemotherapy. Apart from treating colorectal carcinoma, it can also be employed for ovarian cancer and sarcoma management."
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