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Pembrolizumab for Gastroesophageal Junction Cancer

Phase 2
Waitlist Available
Led By Yelena Y Janjigian, MD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial will test whether combining two cancer drugs will help clear tumor DNA from the body after surgery.

Eligible Conditions
  • Gastroesophageal Junction Cancer
  • Gastric Tumor
  • Esophageal Cancer
  • Stomach Cancer
  • Esophageal Tumor
  • Gastroesophageal Cancer
  • Gastroesophageal Junction Adenocarcinoma
  • Gastroesophageal Junction Tumor
  • Esophagogastric Tumors

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of ctDNA Clearance at 6 Months

Trial Design

1Treatment groups
Experimental Treatment
Group I: Trastuzumab and PembrolizumabExperimental Treatment2 Interventions
Trastuzumab will be administered on an every 3 week dosing schedule, with initial loading dose of 8 mg/kg as a 90 minute infusion, followed by trastuzumab 6 mg/kg every 3 weeks. The planned dose of pembrolizumab for this study is 200 mg every 3 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pembrolizumab
2017
Completed Phase 2
~2010
Trastuzumab
2014
Completed Phase 4
~5190

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,933 Previous Clinical Trials
585,619 Total Patients Enrolled
Yelena Y Janjigian, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are currently enrolled in this research study?

"Yes, the data posted on clinicaltrials.gov confirms that recruitment for this study is ongoing. This medical trial was originally published on August 10th 2020 and recently updated in late August 2022. The current goal is to recruit 24 patients from 7 different sites."

Answered by AI

Are there any potential risks associated with the use of Pembrolizumab?

"There is limited clinical data demonstrating the safety of Pembrolizumab, resulting in a rating of 2. No data exists yet to prove its efficacy."

Answered by AI

Are there a range of locations where this investigation is taking place within the state?

"Presently, this study is being conducted at 7 different sites situated in Commack, Montvale and Uniondale as well as 4 other places. It may be advantageous to choose the closest clinic so that your attending-related travel costs are minimized if you participate."

Answered by AI

Are there vacancies for participants in this investigation?

"Affirmative. According to the clinicaltrials.gov registry, this medical research is actively seeking participants with a recruitment timeline beginning on August 10th 2020 and culminating in an update posted on August 29th 2022. In total, there are 24 slots available across 7 trial sites."

Answered by AI

What other investigations have been conducted in relation to Pembrolizumab?

"Currently, 1139 clinical trials are underway to further research pembrolizumab and 170 of those studies have reached Phase 3. These investigations span 49616 medical sites with the majority being in Houston, Texas."

Answered by AI

To what extent has Pembrolizumab been shown to be beneficial for patients suffering from certain ailments?

"Pembrolizumab is oft employed in the treatment of cancerous growths. It can also be effective for patients with unresectable melanoma, a high level of microsatellite instability, and those at risk for relapse."

Answered by AI
~0 spots leftby Apr 2025