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Radiation Therapy for Oropharyngeal Cancer

Phase 2

Waitlist Available

Research Sponsored by Hyunseok Kang, MD

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 18 weeks

Awards & highlights

Study Summary

This trial is testing whether sodium thiosulfate can help prevent hearing loss in patients with head and neck cancer who are also undergoing radiation therapy.

Eligible Conditions

Oropharyngeal Cancer
Head and Neck Cancers
Laryngeal Squamous Cell Carcinoma
Oropharyngeal Carcinoma
Hypopharyngeal Cancer
Laryngeal Cancer
Hypopharyngeal Carcinoma
Squamous Cell Carcinoma
Lip and Oral Cavity Cancer
Oral Squamous Cell Carcinoma

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 18 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 18 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 18 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of patients who successfully completed planned treatment

Secondary outcome measures

Mean Scores on then Hearing Handicap Inventory for Adults - Screening (HHIA-S)

Proportion of participants reporting STS-specific symptomology

Proportion of participants reporting tinnitus by severity

+1 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Cisplatin, Radiotherapy, STSExperimental Treatment4 Interventions

Patients undergo standard of care radiation therapy daily in combination with cisplatin on day 1. Between 4-5 hours after each cisplatin infusion, patients also receive sodium thiosulfate over 1-2 hours on day 1. Treatment will continue on either a 1 week or 3 week cycle per physician discretion for up to 6-7 weeks in the absence of disease progression or unacceptable toxicity.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Cisplatin

2013

Completed Phase 3

~1940

Radiation Therapy

2017

Completed Phase 3

~7250

Sodium Thiosulfate

2014

Completed Phase 3

~90

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Hyunseok Kang, MDLead Sponsor

1 Previous Clinical Trials

10 Total Patients Enrolled

NRG OncologyOTHER

231 Previous Clinical Trials

100,836 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the common diseases that Radiation Therapy can help alleviate?

"Radiation therapy is a common treatment for the harmful effects of cyanide poisoning. It can also help to shrink neoplasms that have metastasized and manage advanced ovarian cancer in patients who haven't responded well to other interventions."

Answered by AI

Could you please provide an estimate for how often serious side effects are seen in patients who undergo Radiation Therapy?

"While there is some data supporting the safety of radiation therapy, it received a score of 2 because, at this stage in development, there is no evidence that it is an effective treatment."

Answered by AI

How many individuals are being monitored in this scientific experiment?

"This particular study is not recruiting right now, as of April 2nd, 2022. However, there are 2862 other studies involving malignant neoplasm of larynx that are currently looking for participants and 784 trials related to Radiation Therapy."

Answered by AI

Are there any open slots for patients in this clinical trial right now?

"The clinical trial's information on clinicaltrials.gov suggests that this study is no longer recruiting patients. The study was first posted on October 14th 2020, and updated for the last time on April 2nd 2022. There are 3646 other studies that are actively recruiting at this moment."

Answered by AI

Are there any other examples in the medical literature of Radiation Therapy being used?

"784 clinical trials for Radiation Therapy are ongoing and 302 of them have progressed to Phase 3. Most these medical trials are based in Shanghai, China; however, there are 4,234 total locations running clinical trials for this treatment option."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin

Hyunseok Kang, MD 2020. "Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04541355.