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Alpha-1 Agonist

Study 1 for Spinal Cord Injury

Phase 2
Waitlist Available
Led By Jill M Wecht, Ed.D
Research Sponsored by James J. Peters Veterans Affairs Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury

Eligible Conditions
  • Spinal Cord Injury
  • Autonomic Dysfunction
  • Vagal Integrity
  • High Blood Pressure
  • Cerebral Blood Flow
  • Baroreceptor Integrity
  • Low Blood Pressure
  • Cognitive Functioning
  • Autonomic Dysreflexia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cerebral Blood Flow
Systolic Blood Pressure

Trial Design

2Treatment groups
Experimental Treatment
Group I: Study 2Experimental Treatment4 Interventions
Study2: is a randomized placebo-controlled double-blinded investigation to determine the effect of the normalization of SBP on cerebral blood flow, cognitive function (memory and attention processing) and quality of life. The investigator will be using midodrine hydrochloride, pyridostigmine bromide, mirabegron and placebo.
Group II: Study 1Experimental Treatment3 Interventions
Study 1: is a dose escalation to determine the individualized dose of each of 3 medications (midodrine, pyridostigmine, mirabegron) that increases SBP into the normal range (111-139 mmHg). The investigator will be using midodrine hydrochloride, pyridostigmine bromide and mirabegron.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Midodrine
FDA approved
Pyridostigmine
FDA approved
Mirabegron
FDA approved

Find a Location

Who is running the clinical trial?

Kessler FoundationOTHER
173 Previous Clinical Trials
10,673 Total Patients Enrolled
James J. Peters Veterans Affairs Medical CenterLead Sponsor
57 Previous Clinical Trials
2,859 Total Patients Enrolled
Jill M Wecht, Ed.DPrincipal InvestigatorJames J. Peters VA Medical Center
2 Previous Clinical Trials
82 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Jill M. Wecht, Ed.D. 2016. "The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02893553.
~5 spots leftby Apr 2025
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