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Vitamin
Vitamin C for Sepsis
Phase 2
Waitlist Available
Led By Michael D Sharpe, MD FRCPC
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days or discharge from intensive care unit
Awards & highlights
Study Summary
This study is designed to determine if Vitamin C administration to septic patients will result in an improvement in organ dysfunction which occurs during a septic illness. Hypothesis: 1. Vitamin C in sepsis will reduce the injury to organs 2. Vitamin C will reduce the length of time on a ventilator, length of stay in the intensive care unit and in hospital.
Eligible Conditions
- Sepsis
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 28 days or discharge from intensive care unit
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days or discharge from intensive care unit
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Sequential organ function assessment score (SOFA)
Secondary outcome measures
Biomarkers as a measure of coagulation, inflammation and oxidative stress.
Side effects data
From 2018 Phase 2 trial • 20 Patients • NCT0314823610%
Pericarditis
100%
80%
60%
40%
20%
0%
Study treatment Arm
Vitamin C
Placebo
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Vitamin CExperimental Treatment1 Intervention
Intravenous Vitamin C will be administered (1 gram) every 8 hours for 28 days or discharge from intensive care unit
Group II: placeboPlacebo Group1 Intervention
placebo vehicle administered in same fashion as active treatment
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ascorbic acid
FDA approved
Find a Location
Who is running the clinical trial?
Lawson Health Research InstituteLead Sponsor
659 Previous Clinical Trials
413,712 Total Patients Enrolled
5 Trials studying Sepsis
1,750 Patients Enrolled for Sepsis
Michael D Sharpe, MD FRCPCPrincipal InvestigatorLondon Health Sciences Centre
2 Previous Clinical Trials
54 Total Patients Enrolled
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