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Anti-oxidant

N-acetyl cysteine for Suicide

Phase 2
Waitlist Available
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days
Awards & highlights

Study Summary

This trial measured changes in a brain chemical called glutathione in people with and without self-injury, after taking a supplement called N-acetylcysteine.

Eligible Conditions
  • Suicide
  • Self-Harm
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent Increase in Glutathione (GSH) Concentrations in the ACC
Secondary outcome measures
Change in GSH Reduced-to-oxidized Ratio
Change in Glutamate Concentrations

Side effects data

From 2022 Phase 2 trial • 44 Patients • NCT04005053
36%
Psychiatric
36%
Gastrointestinal
100%
80%
60%
40%
20%
0%
Study treatment Arm
Low-Dose NAC
Placebo
High-Dose NAC

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Low-Dose NACExperimental Treatment1 Intervention
3600 NAC mg/day
Group II: High-Dose NACExperimental Treatment1 Intervention
5400 NAC mg/day
Group III: PlaceboPlacebo Group1 Intervention
Placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
N-acetyl cysteine
2016
Completed Phase 4
~990

Find a Location

Who is running the clinical trial?

University of MinnesotaLead Sponsor
1,377 Previous Clinical Trials
1,588,253 Total Patients Enrolled
5 Trials studying Suicide
1,292 Patients Enrolled for Suicide

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Journal of Psychiatry and Brain ScienceJournal
Identifying Biological Signatures of N-acetylcysteine for Non-suicidal Self-injury in Adolescents and Young Adults
“Identifying Biological Signatures of N-acetylcysteine for Non-suicidal Self-injury in Adolescents and Young Adults”. 2021. “Identifying Biological Signatures of N-acetylcysteine for Non-suicidal Self-injury in Adolescents and Young Adults”. Journal of Psychiatry and Brain Science. Hapres. doi:10.20900/jpbs.20210007.
clinicaltrials.govStudy
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
2019. "Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04005053.
~8 spots leftby Apr 2025
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