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Opioid

Methadone for Scoliosis

Phase 3
Waitlist Available
Led By Roger A Fons, MD
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 72 hours
Awards & highlights

Study Summary

This trial found that perioperative methadone use decreases postoperative pain and the need for opioids in children having scoliosis surgery.

Eligible Conditions
  • Scoliosis
  • Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~72 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 72 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Post-operative Opioid Consumption (mg/kg)
Secondary outcome measures
Constipation
Itching as assessed by number of doses of benadryl required post-operatively
Nausea as assessed by number of doses of ondansetron required post-operatively
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Methadone GroupExperimental Treatment2 Interventions
Patients will receive a total of 0.2mg/kg IV methadone intraoperative (0.1mg / kg preincision and 0.1mg/kg prior to emergence) with a maximum dosing of 20 mg.
Group II: Control GroupActive Control2 Interventions
Patient will receive normal saline placebo initially, then morphine prior to emergence.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Methadone
2005
Completed Phase 4
~2930
Morphine
2013
Completed Phase 4
~2230

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor
609 Previous Clinical Trials
1,162,525 Total Patients Enrolled
1 Trials studying Scoliosis
10 Patients Enrolled for Scoliosis
Steven Weisman, MDStudy ChairChildren's Hospital and Health System Foundation, Wisconsin
Roger A Fons, MDPrincipal Investigator - Children's Hospital and Health System Foundation, Wisconsin
Children's Hospital of Wisconsin
University Of Wisconsin Medical Sch (Medical School)
Medical College Wi Affil Hosps, Inc (Residency)

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the potential dangers of Methadone for patients?

"There is some evidence from previous clinical trials to suggest that Methadone is effective and safe. Our team has rated it a 3 on our scale."

Answered by AI

How many people are taking part in this experiment at most?

"This study has concluded its recruitment drive. The original posting date was May 1st, 2016 with the most recent edit on October 12th, 2022. However, there are 444 other trials currently underway that focus on pain and 69 clinical trials involving Methadone that are actively searching for patients."

Answered by AI

What are the main indications for Methadone treatment?

"Methadone is an effective therapeutic intervention for patients struggling with pain and opioid addiction."

Answered by AI

Could you please provide a list of other studies that have used Methadone?

"There are currently 69 ongoing studies researching Methadone. 18 of those live studies are in Phase 3, with the majority taking place in Amersfoort, Noord Holland. However, there are a total of 165 locations running studies for this treatment across the world."

Answered by AI

Are people of all ages being studied in this clinical trial?

"According to the age bracket that is eligible for this study, the minimum age requirement is 10 years old and the maximum is 18."

Answered by AI

How can I become a participant in this research?

"The aim of this trial is to enrol 44 participants who are aged between 10-18 years old and experience pain. Other inclusion criteria for the study are as follows: Idiopathic scoliosis, Fusion levels planned for 10 or greater."

Answered by AI

Does this experimental research have any historical precedent?

"There are currently 69 ongoing clinical trials for Methadone in 85 cities and 15 countries. The first trial was sponsored by Laboratoires Bouchara-Recordati in 2011 and completed Phase 3 drug approval with the involvement of 146 patients. Since then, an additional 720 studies have concluded."

Answered by AI

Are people currently being recruited for this test?

"The trial you are inquiring about is not recruiting patients at this moment. The study was originally posted on May 1st, 2016 and was last edited on October 12th, 2022. However, there are 444 other studies seeking participants who experience pain and 69 studies investigating Methadone currently enrolling patients."

Answered by AI
Recent research and studies
~6 spots leftby Apr 2025