Treatment for HIV Infections

Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Illinois Masonic Med Ctr / The Cancer Ctr, Chicago, IL
HIV Infections+2 More
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a new drug called Stealth liposomal doxorubicin hydrochloride (DOX-SL) is better than the standard drug called Adriamycin (doxorubicin)/bleomycin/vincristine (ABV) in

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Eligible Conditions

  • HIV Infections
  • Sarcoma, Kaposi

Treatment Effectiveness

Effectiveness Estimate

2 of 3
This is better than 85% of similar trials

Trial Safety

Safety Estimate

3 of 3
This is better than 85% of similar trials

Trial Design

0 Treatment Group

This trial requires 225 total participants across 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 5 years for reporting.

Closest Location

Illinois Masonic Med Ctr / The Cancer Ctr - Chicago, IL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Prophylaxis for PCP, cryptococcal, and herpes infections, and antiretroviral therapy (e.g., AZT, ddC, ddI) provided these doses have been stable for at least 1 month.
Therapy for tuberculosis, fungal, and herpes infections except with potentially myelotoxic chemotherapy.
Foscarnet for new episodes of cytomegalovirus infection.
Colony-stimulating factors and erythropoietin.
At least 25 mucocutaneous lesions.
Ten or more new lesions in the prior month.
Documented visceral disease with at least two accessible cutaneous lesions.
Two accessible cutaneous lesions with edema.
Documented anti-HIV antibody.
No active opportunistic infection with mycobacteria, cytomegalovirus, toxoplasma, Pneumocystis carinii, or other microorganisms (if under treatment with myelotoxic drugs).

Patient Q&A Section

Can sarcoma be cured?

"There is no curative treatment for sarcoma and survival rate is related to treatment strategy. The overall 5-year survival rate is less than 20%. The curative treatment of metastatic sarcoma is not completely understood and remains a challenge for sarcoma oncologists." - Anonymous Online Contributor

Unverified Answer

How many people get sarcoma a year in the United States?

"The American Cancer Society estimates 24,780 new cases of sarcoma are expected to be diagnosed in the United States in 2019. This makes up 1.5% of all cancer diagnoses in the United States. Patients under the age of 20 account for 20% of all sarcoma diagnoses. Most tumors diagnosed from sarcoma are STS (sarcoma of the soft tissue) (60%), while leiomyosarcoma is the next most common (15%).\n" - Anonymous Online Contributor

Unverified Answer

What causes sarcoma?

"A complex and multifactorial causation may be underway in sarcomas, with some common cancers being caused directly, others by metastasis from other cancers, and some being caused through long-term exposure to environmental carcinogens. Understanding sarcomas will assist in developing strategies for controlling risk factors associated with these uncommon cancers." - Anonymous Online Contributor

Unverified Answer

What are common treatments for sarcoma?

"Given the diversity of the tumors encountered in sarcoma, there is considerable scope for variation in the treatment used. Most common treatments include surgery (including amputations), radiation therapy, chemotherapy, targeted therapy and imaging guided surgery." - Anonymous Online Contributor

Unverified Answer

What is sarcoma?

"Currently there is still no known cure to sarcoma. Even in the case where treatment is successful, sarcoma can go into a malignant phase. It is estimated that less than 5% of people have lymphomas. These cancerous malady are caused by chromosomal, viral or bacterial infection and are thought to form in the body cells causing them to invade or spread throughout the body. Treatment ranges from topical treatment, surgery and chemotherapy to chemotherapy and radiation therapy. Lymphoma is a type of cancer in which white blood cells are affected by the cancer. Lymphoma is the 7th most common cancer among American men and the 12th most common among American women." - Anonymous Online Contributor

Unverified Answer

What are the signs of sarcoma?

"Sarcoma involves the soft and/or hard tissue. As tumour sites are highly vascular as well as of slow growing, they allow tumour progression due to an increase in capillary blood flow and tumour mass. Rapid and progressive tumour enlargement is the mainstay of the signs of sarcomas. Thus, enlarged and thick tumours are indicators for the histopathological diagnosis of sarcoma. Inadequate evaluation of a sarcoma at time of diagnosis often results in inadequate treatment to avoid life-threatening complications. Imaging techniques are, however, helpful in diagnosis and follow-up imaging, especially CT scan and MRI." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"Results from a recent paper almost 50% of respondents were treatment naive and used conventional treatment solely; the rest used treatment in combination with surgery, chemotherapy, radiotherapy/targeted therapy and immune-targeted therapy. The use of treatment combinations varies according to disease type, organ site of origin and the respondent’s opinion and expectations (i.e. the person believes that treatment will cure the disease)." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"There is much controversy on the optimal treatment for non-surgical/chemo-therapy treated patients and in this topic, there is some ambiguity. There is still no consensus on what to do once patients are treated in this way. We also see this in the field of oncology as there is not a clear consensus on treatment in metastatic solid tumors and the type of metastasis being treated as well, nor with patients who are at risk of relapse which means their disease comes back after treatment has successfully healed or stabilized them or that they relapse after the first remission of their cancer." - Anonymous Online Contributor

Unverified Answer

How quickly does sarcoma spread?

"In our study, there were no patients with in-situ tumors. The most common metastatic involvement of the lung, in which primary disease is most likely to develop, was at the time of lung biopsy. We recommend staging of asymptomatic, low-grade sarcoma patients with repeat CT scans in 3–6 months." - Anonymous Online Contributor

Unverified Answer

Does sarcoma run in families?

"Families in which sarcoma was documented as a genetic predisposition were of mixed Caucasian and indigenous backgrounds. Sarcomas developed at approximately the same age in siblings. Although further studies with larger sample numbers are required to validate these findings, the study indicates that sarcoma is not genetically recessive (i.e. has a high penetrance) or, although autosomal, can be under-reported." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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