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Diuretic

Chlorthalidone for High Blood Pressure (CLICK Trial)

Phase 2

Waitlist Available

Led By Rajiv Agarwal, MD

Research Sponsored by Indiana University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to 12 weeks

Awards & highlights

CLICK Trial Summary

This trial found that while thiazide diuretics are not as potent as loop diuretics, they may be associated with less acute kidney injury.

Eligible Conditions

High Blood Pressure
Chronic Kidney Disease

CLICK Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to 12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change From Baseline to 12 Weeks in Systolic Ambulatory Blood Pressure in the Chlorthalidone Group Compared to Placebo.

Secondary outcome measures

Change From Baseline at Each 4 Week Visit in Body Volume in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons.

Change From Baseline at Each 4 Week Visit in Log of Aldosterone and Log of Renin in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons.

Change From Baseline at Each 4 Week Visit in Log of N-terminal Pro B-type Natriuretic Peptide (NTproBNP) in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons.

+1 more

Side effects data

From 2014 Phase 4 trial • 839 Patients • NCT01203852

Other

Headache

Fatigue

Dizziness

Nausea

100%

80%

60%

40%

20%

Study treatment Arm

All Study Participants

CLICK Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: ChlorthalidoneExperimental Treatment1 Intervention

Subjects with stage 4 chronic kidney disease (CKD) and poorly controlled hypertension confirmed by 24 hour ambulatory blood pressure monitoring will be randomized into two groups, one receiving placebo and one receiving a diuretic called chlorthalidone (12.5 mg at randomization). Doubling of the dose of the diuretic (up to 50 mg) or placebo will occur every 4 weeks if required by home blood pressure (BP) results.

Group II: PlaceboPlacebo Group1 Intervention

Subjects with stage 4 CKD and poorly controlled hypertension confirmed by 24 hour ambulatory blood pressure monitoring will be randomized into two groups, one receiving placebo and one receiving a diuretic called chlorthalidone (12.5 mg at randomization). Doubling of the dose of the diuretic (up to 50 mg) or placebo will occur every 4 weeks if required by home BP results.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Chlorthalidone

2013

Completed Phase 4

~55260

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Find a Location

Who is running the clinical trial?

Indiana UniversityLead Sponsor

980 Previous Clinical Trials

983,001 Total Patients Enrolled

Rajiv Agarwal, MDPrincipal InvestigatorIndiana University

5 Previous Clinical Trials

381 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What potential side effects should one be aware of when taking Chlorthalidone?

"Although there is limited evidence indicating Chlorthalidone's efficacy, it has been assessed to have a safety rating of 2."

Answered by AI

What maladies is Chlorthalidone typically administered to address?

"Chlorthalidone is widely employed to address edema. Its additional indications include nephrolithiasis, hypertensive disease and other kidney pathologies."

Answered by AI

Has Chlorthalidone been evaluated in any other clinical investigations?

"Currently, seven clinical trials are researching the effects of Chlorthalidone; three of which have entered Phase 3. While these studies originated from Houston, Texas, they span 74 different sites worldwide."

Answered by AI

Is this research recruiting participants at present?

"This medical trial is no longer actively recruiting. Initially posted on July 1st 2016, the clinical research was last updated on March 4th 2022. Alternative studies may be available; there are 1140 trials searching for patients presenting with hypertension and 7 separate experiments enrolling participants taking Chlorthalidone."

Answered by AI

How many participants are being recruited for this trial?

"At the moment, this trial is no longer recruiting new participants. It was initially posted on July 1st 2016 and last edited on March 4th 2022. For those seeking other clinical trials to participate in, 1140 studies are looking for patients with hypertension and 7 studies require subjects taking Chlorthalidone."

Answered by AI

Recent research and studies

American Journal of NephrologyJournal

Design and Baseline Characteristics of the Chlorthalidone in Chronic Kidney Disease (CLICK) Trial

Agarwal, Rajiv, Andrew E. Cramer, Mary Balmes-Fenwick, Arjun D. Sinha, Fangqian Ouyang, and Wanzhu Tu. 2020. “Design and Baseline Characteristics of the Chlorthalidone in Chronic Kidney Disease (CLICK) Trial”. American Journal of Nephrology. S. Karger AG. doi:10.1159/000508700.

New England Journal of MedicineJournal

Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease

Agarwal, Rajiv, Arjun D. Sinha, Andrew E. Cramer, Mary Balmes-Fenwick, Jazmyn H. Dickinson, Fangqian Ouyang, and Wanzhu Tu. 2021. “Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmoa2110730.

New England Journal of MedicineJournal

Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease

clinicaltrials.govStudy

Chlorthalidone in Chronic Kidney Disease