CLINICAL TRIAL

Treatment for Kidney Failure

Recruiting · 18+ · All Sexes · Dallas, TX

This study is evaluating whether a reversal drug for rocuronium and cisatracurium may help reduce the amount of time it takes for a patient to wake up after surgery.

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About the trial for Kidney Failure

Eligible Conditions
Renal Insufficiency · Neuromuscular Blockade · deteriorating renal function

Treatment Groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Control Group 1
Rocuronium + Sugammadex
DRUG
Control Group 2
Cisatracurium + Neostigmine
DRUG

Eligibility

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
18-80 years old
Severe renal impairment (CrCl < 30 mL/min)
Undergoing non-emergent surgery that requires neuromuscular blockade
Planned extubation in the operating room immediately after surgery
American Society of Anesthesiologists (ASA) physical status classification 3 to 4
Willing and able to consent in English or Spanish
No personal history of neuromuscular disease
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: In the operating room from induction to extubation.
Screening: ~3 weeks
Treatment: Varies
Reporting: In the operating room from induction to extubation.
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: In the operating room from induction to extubation..
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Treatment will improve 1 primary outcome in patients with Kidney Failure. Measurement will happen over the course of In the operating room from induction to extubation..

Time until complete reversal of neuromuscular blockade
IN THE OPERATING ROOM FROM INDUCTION TO EXTUBATION.
Measure how long it takes to return from a TOF of 2 to a TOF ≥ 0.9.
IN THE OPERATING ROOM FROM INDUCTION TO EXTUBATION.

Who is running the study

Principal Investigator
T. B. M.
Prof. Tiffany B Moon, ASSOC PROFESSOR
University of Texas Southwestern Medical Center

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can kidney failure be cured?

Failure of dialysis treatment to support proper nutrition and fluid balance can result in substantial morbidity before death. Death can be delayed with dialysis and prompt application of renal replacement therapy.

Anonymous Patient Answer

What is kidney failure?

Kidney failure affects around 13% of European adults per year and 20% of adults over the age of 65 years per year in the UK. Most people with CKD would have been undiagnosed if a kidney disease registry had not been established in the UK and an assessment performed at the point of diagnosis.

Anonymous Patient Answer

What are common treatments for kidney failure?

Treatment for kidney failure is tailored to the severity of kidney disease and other comorbidities. Treatments range from support, dialysis, and [kidney transplant](https://www.withpower.com/clinical-trials/kidney-transplant)s to dialysis, transplant, and kidney death.\n

Anonymous Patient Answer

How many people get kidney failure a year in the United States?

This article describes how many people in the United States develop kidney failure each year. The lifetime risk of developing end stage kidney failure is 13-20% for whites and blacks and 16% for whites and Hispanics. In addition, the rate of dialysis initiation rises steadily to 41% by the age of 65, where it is expected to peak. In summary, the number of new cases of end stage kidney failure will increase steadily over the next decade.

Anonymous Patient Answer

What causes kidney failure?

The kidney contributes significantly to cardiovascular health by regulating multiple body fluids and maintaining electrolyte concentrations, kidney function is impaired by kidney failure. There is a lack of data on the risk factors of kidney failure and their treatment, as well as an information deficit for the general public on renal disease.

Anonymous Patient Answer

What are the signs of kidney failure?

The diagnosis of kidney failure should be considered in people with the following medical problems: unexplained weight loss, feeling unwell, high bilirubin, feeling tired, bruising and bleeding gums. Other, less common, signs of kidney failure include low urine volume, jaundice, fever, and abdominal pain. These signs may occur before any other symptoms.\n

Anonymous Patient Answer

Have there been other clinical trials involving treatment?

A large number of clinical trials have investigated treatments for kidney disease. It is unclear from what they found out whether these trials can be replicated. More trials need to be conducted or replicated to help develop strategies which improve the outcomes and experiences of patients and clinicians.

Anonymous Patient Answer

Does kidney failure run in families?

Patients with a first episode of kidney failure due to PKD should be closely followed for development of CKD. In those patients that develop CKD, the development of CKD may be associated with the presence of an increased number of first-degree relatives with CKD and with a trend towards increased prevalence of diabetes mellitus.

Anonymous Patient Answer

Is treatment typically used in combination with any other treatments?

The use of treatment is typically in combination with another treatment, with the most frequently used combination being the corticosteroid plus a thiazide diuretic. There is a clear need for trials addressing this, especially for trials funded by the government, which may benefit from any other funding.

Anonymous Patient Answer

What is the average age someone gets kidney failure?

This is the first study to show the average age someone gets kidney failure over the years. It shows that it is more common in children before they get to 20 years old and that many people get it at much younger ages like 13 or 15. Other countries besides France show similar findings.

Anonymous Patient Answer

What is the primary cause of kidney failure?

The primary cause of kidney failure is glomerulo-proliferative disorders. Glomeruli that show podocyte foot process effacement and podocyte hyperplasia may also develop glomerular sclerosis, leading to kidney failure. Furthermore, the primary cause of kidney failure is kidney dysfunction secondary to tubulo-interstitial diseases.

Anonymous Patient Answer

Has treatment proven to be more effective than a placebo?

The effect of treatment on survival of subjects with progressive chronic kidney disease is only modest relative to the risk of death from competing causes.

Anonymous Patient Answer
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