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[F-18] DCFPyL for Prostate Cancer

Phase 2
Waitlist Available
Led By Emerson Lim, MD
Research Sponsored by Emerson Lim
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, up to 1 year
Awards & highlights

Study Summary

This trial is testing whether a certain imaging scan can help predict how well someone with metastatic prostate cancer will respond to treatment.

Eligible Conditions
  • Prostate Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, up to 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, up to 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Prevalence of changes in PyL PET imaging correlating with radiographic Progression-Free Survival (rPFS)
Secondary outcome measures
Change in number of lesions detected with standard imaging at baseline and at the time of progression
Prevalence of baseline SUVmax correlating with rPFS
Prevalence of changes in uptake of [18F]DCFPyL PET/CT scans correlating with Overall Survival (OS)

Trial Design

1Treatment groups
Experimental Treatment
Group I: PyL-PETExperimental Treatment2 Interventions
Male participants diagnosed with metastatic castrate resistant prostate cancer (mCRPC) and are scheduled to start a new treatment will receive [F-18] DCFPyL PET/CT imaging before starting new treatment and after 6 weeks on treatment.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PET/CT imaging
2021
Completed Phase 3
~430

Find a Location

Who is running the clinical trial?

Emerson LimLead Sponsor
Columbia UniversityLead Sponsor
1,431 Previous Clinical Trials
2,460,820 Total Patients Enrolled
14 Trials studying Prostate Cancer
22,592 Patients Enrolled for Prostate Cancer
Emerson Lim, MDPrincipal InvestigatorColumbia University
2 Previous Clinical Trials
138 Total Patients Enrolled
1 Trials studying Prostate Cancer
9 Patients Enrolled for Prostate Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Molecular Imaging and BiologyJournal
Psma-based [18f]dcfpyl PET/CT Is Superior to Conventional Imaging for Lesion Detection in Patients with Metastatic Prostate Cancer
Rowe, Steven P., Katarzyna J. Macura, Esther Mena, Amanda L. Blackford, Rosa Nadal, Emmanuel S. Antonarakis, Mario Eisenberger, et al.. 2016. “Psma-based [18f]dcfpyl PET/CT Is Superior to Conventional Imaging for Lesion Detection in Patients with Metastatic Prostate Cancer”. Molecular Imaging and Biology. Springer Science and Business Media LLC. doi:10.1007/s11307-016-0957-6.
CA: A Cancer Journal for CliniciansJournal
Cancer Statistics, 2017
Siegel, Rebecca L., Kimberly D. Miller, and Ahmedin Jemal. 2017. “Cancer Statistics, 2017”. CA: A Cancer Journal for Clinicians. Wiley. doi:10.3322/caac.21387.
Molecular Imaging and BiologyJournal
Initial Evaluation of [18f]dcfpyl for Prostate-specific Membrane Antigen (psma)-targeted PET Imaging of Prostate Cancer
Szabo, Zsolt, Esther Mena, Steven P. Rowe, Donika Plyku, Rosa Nidal, Mario A. Eisenberger, Emmanuel S. Antonarakis, et al.. 2015. “Initial Evaluation of [18f]dcfpyl for Prostate-specific Membrane Antigen (psma)-targeted PET Imaging of Prostate Cancer”. Molecular Imaging and Biology. Springer Science and Business Media LLC. doi:10.1007/s11307-015-0850-8.
clinicaltrials.govStudy
Prostate Cancer Monitoring Using [18F]DCFPyL and Blood Based Biomarkers
Matthew Dallos 2018. "Prostate Cancer Monitoring Using [18F]DCFPyL and Blood Based Biomarkers". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03585114.
~2 spots leftby Apr 2025
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