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Chemoprotective Agent
Amifostine for Myelodysplastic Syndrome
Phase 2
Waitlist Available
Research Sponsored by Providence Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Histologically proven advanced myelodysplastic syndrome (MDS) including refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, MDS with at least bicytopenia, no chronic myelomonocytic leukemia, no acute leukemia
Performance Status ECOG 0-2
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying how well amifostine works in treating patients with advanced myelodysplastic syndrome.
Who is the study for?
This trial is for adults (17+) with advanced myelodysplastic syndrome, which includes various types of refractory anemia. Participants must have low blood counts but no acute leukemia or chronic myelomonocytic leukemia. They should be relatively active (ECOG 0-2), not pregnant, and willing to use contraception.Check my eligibility
What is being tested?
The trial is testing the effectiveness of Amifostine in improving blood counts in patients with advanced myelodysplastic syndrome. It's a Phase II study, meaning it focuses on how well the drug works and further evaluates its safety.See study design
What are the potential side effects?
Amifostine may cause side effects such as nausea, vomiting, allergic reactions, low blood pressure, dizziness upon standing up quickly due to lowered blood pressure, and flushing.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have a confirmed advanced type of anemia not linked to leukemia.
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I can take care of myself and perform daily activities.
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I am 17 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Find a Location
Who is running the clinical trial?
Providence HospitalLead Sponsor
4 Previous Clinical Trials
4,159 Total Patients Enrolled
Howard R. Terebelo, DOStudy ChairProvidence Hospital
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have previously taken leucovorin calcium and pyridoxine.My kidneys are functioning well.I have previously taken steroid therapy.I have a confirmed advanced type of anemia not linked to leukemia.My liver is functioning well.I can take care of myself and perform daily activities.I am 17 years old or older.I haven't had chemotherapy, but I may have had cytokine therapy.I do not have serious heart disease.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Has this therapy acquired governmental sanction from the FDA?
"As this trial is in Phase 2, there are some data indicating safety; however, efficacy has yet to be established. Therefore, the team at Power rated its safety as a score of 2."
Answered by AI
Are there any open positions available to join this research?
"Clinicaltrials.gov reveals that this research endeavor is not currently seeking participants, despite being initiated in August of 1997 and last updated November 5th 2013. Nevertheless, there are 1,595 other trials actively enrolling patients at this time."
Answered by AI
What is the geographical scope of this trial?
"Currently, seven medical centres are recruiting participants for this trial. These locations span from Detroit to Cleveland and some other cities in between. For convenience sake, it is advisable that individuals look for a clinic closest to them so as to reduce the burden of travel if they decide to participate."
Answered by AI
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