Treatment for Precancerous Conditions

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
New Jersey Medical School, Newark, NJ
Precancerous Conditions+1 More
Eligibility
Any Age
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a vaccine made from papilloma virus cells can help treat recurrent laryngeal papilloma in young patients.

See full description

Eligible Conditions

  • Precancerous Conditions

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Precancerous Conditions

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Other trials for Precancerous Conditions

Trial Design

0 Treatment Group

This trial involves 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 5 years for reporting.

Closest Location

New Jersey Medical School - Newark, NJ

Eligibility Criteria

This trial is for patients born any sex of any age. You must have received 1 prior treatment for Precancerous Conditions or the other condition listed above. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
DISEASE CHARACTERISTICS: Diagnosis of severe recurrent juvenile papilloma of the larynx requiring surgery at least 4 times per year Condition must have existed for more than 1 year
PATIENT CHARACTERISTICS: Age: 1 and over Performance status: Not specified Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified
PRIOR CONCURRENT THERAPY: See Disease Characteristic

Patient Q&A Section

Is treatment safe for people?

"Inclusion of the majority of the patients in the cohort in a clinical trial was possible. Side effects were minimal, mostly of mild degree, and related to the underlying condition." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"Different patients need different treatments depending on the type and stage of breast cancer. Most patients require treatment that could have profound effects on their quality of life. Appropriate treatment is crucial. Some treatments are used often with little knowledge of their optimal use." - Anonymous Online Contributor

Unverified Answer

Does papilloma run in families?

"Despite a large family history of papillary fibroelastoma, many patients who have multiple papules will not have papilledema and/or papillary fibroelastoma, demonstrating the significance of the genetic component. This observation may assist in counseling patients prior to elective cataract or keratoplasty." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"Although definitive data are lacking in this area, results from one study suggest that treatment by itself may not be sufficient to achieve complete clinical remission in a majority of patients with benign nodular papilloma, given standard of care combined with other standard treatments, including surgical resection." - Anonymous Online Contributor

Unverified Answer

What is papilloma?

"Papilloma is generally considered a benign lesion. Although benign in essence, papilloma should not be ignored and should be considered in the differential diagnosis of a neoplastic process. Histopathology and immunohistochemistry of the papilloma may shed light on its origin." - Anonymous Online Contributor

Unverified Answer

What are common treatments for papilloma?

"Many papillomas can be managed with a course of nonsteroidal anti-inflammatory drugs. For larger lesions, the patient should see their doctor about laser therapy and discuss the potential risk of getting an initial squamous cell carcinoma if the diagnosis is made in the wrong place. Most keratoacanthomas are best managed with simple cosmetic measures." - Anonymous Online Contributor

Unverified Answer

Can papilloma be cured?

"Most papillomas are asymptomatic or minor skin lesions. There is a trend toward increased mortality for patients with papillomas and a five-fold increased risk of developing malignant neoplasms. However, because of short follow-up periods and small number of lesions, long-term evaluation of papilloma patients is difficult." - Anonymous Online Contributor

Unverified Answer

What are the signs of papilloma?

"Infections such as condyloma acuminatum and warts can be associated with papillomas. A wart or discharge at the site of a papilloma implies the possibility of a sexually transmitted infection." - Anonymous Online Contributor

Unverified Answer

What causes papilloma?

"There is growing evidence of genetic predisposition in the majority of cases, especially when occurring in families. The risk is greater for the elderly and for people with non-melanoma skin type. The role of ultraviolet radiation in triggering the growth of these lesions remains uncertain." - Anonymous Online Contributor

Unverified Answer

How many people get papilloma a year in the United States?

"Nearly 40,000 people per year have papilloma of the oral mucosa (oral submucous fibrosis). These cases are typically diagnosed at the second-lowest national income level (low income households) and are more common among women than men. Oral papilloma is more common at younger age, is more severe, and has more advanced stages. Oral papilloma is usually associated with other oral diseases, particularly oral submucous fibrosis, oral premalignant lesions, and oral cancer. Oral papilloma is also highly comorbid with other oral diseases. We suspect that oral papilloma may be a predisposing or modifying factor for oral cancer and potentially other oral diseases." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving treatment?

"Many types of treatment are being used. Unfortunately, only 5 trials of treatment were reported in the last 3 years; the majority of patients continue to be treated by standard management. If we can identify effective treatment that prevents long-term side effects and prevents relapse, this will be the most effective prevention intervention. Future randomized controlled trials would need to be conducted during a long period with no treatments. However, we can say that since many patients are continuing to be treated they will need to be followed up and monitored carefully." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating papilloma?

"Only 3% of patients on our website experienced complete regression of their PPG. Even though we did not find any studies in which the treatment of papilloma was studied, we did find papers on the medical and surgical treatment of papilloma. All found that surgery is the treatment of choice. We hope to create a database for this condition to give the patients the latest and latest evidence on the condition. We would like more clinical trials to be performed to study the effectiveness of other forms of therapies." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Precancerous Conditions by sharing your contact details with the study coordinator.