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Probiotic Therapy

SYNB1618 for Phenylketonuria (SynPheny-1 Trial)

Phase 2
Waitlist Available
Research Sponsored by Synlogic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 43
Awards & highlights

SynPheny-1 Trial Summary

This study is evaluating whether a drug may help treat a genetic disorder.

Eligible Conditions
  • Phenylketonuria

SynPheny-1 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 43
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 43 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes from baseline in labeled Phe (D5-Phe) in plasma
Secondary outcome measures
Changes from baseline in fasting levels of plasma Phe
Incidence of Treatment-Emergent Adverse Events

SynPheny-1 Trial Design

2Treatment groups
Experimental Treatment
Group I: SYNB1934Experimental Treatment1 Intervention
Dose ramp of SYNB1934
Group II: SYNB1618Experimental Treatment1 Intervention
Dose ramp of SYNB1618
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
SYNB1934
2021
Completed Phase 2
~130
SYNB1618
2021
Completed Phase 2
~200

Find a Location

Who is running the clinical trial?

SynlogicLead Sponsor
9 Previous Clinical Trials
480 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Efficacy and Safety of SYNB1618 and SYNB1934 in Adult Patients With Phenylketonuria
2020. "Efficacy and Safety of SYNB1618 and SYNB1934 in Adult Patients With Phenylketonuria". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04534842.
~4 spots leftby Apr 2025
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