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Ibuprofen and acetaminophen for Postoperative Pain (MOPAC Trial)
MOPAC Trial Summary
This trial is testing if a combination of acetaminophen and ibuprofen is more effective than ibuprofen alone in relieving post-operative pain for patients who have had a Cesarean delivery.
- Postoperative Pain
- Opioid Use Disorder
MOPAC Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.MOPAC Trial Design
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Who is running the clinical trial?
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- You have a history of using opioids, illegal drugs, or having a problem with alcohol either before or during your pregnancy.You have serious problems with your kidneys or liver.You have previously had a cesarean section with a horizontal incision on the lower part of the uterus.You had a serious complication during or after surgery, and your doctor advises against taking non-steroidal anti-inflammatory drugs. You may need to take acetaminophen to treat fever.You have an allergy or medical condition that makes it unsafe for you to take the study medication.
- Group 1: Ibuprofen and placebo
- Group 2: Ibuprofen and acetaminophen
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the most up-to-date information on Ibuprofen and acetaminophen's FDA approval status?
"Both Ibuprofen and acetaminophen have extensive Phase 3 trial data supporting their efficacy and safety, so they each received a score of 3."
How many test subjects are a part of this experiment?
"The clinicaltrials.gov website contains information indicating that this study is currently looking for patients to enroll. This trial was originally posted on 8/5/2019, and the most recent update was on 9/26/2022. A total of 144 patients are needed from 1 location."
Are new participants currently being sought for this experiment?
"From what is available on clinicaltrials.gov, this study is still recruiting patients and seeking new participants. The trial was originally posted on 8/5/2019, with the most recent update being 9/26/2022."
Could you please list other research projects that have studied Ibuprofen and acetaminophen?
"Currently, there are 118 ongoing trials studying the effects of ibuprofen and acetaminophen. Of these active studies, 36 are in Phase 3. Most of the research regarding Ibuprofen and acetaminophen is centred in Pittsburgh, Pennsylvania; however, there are 1037 locations running these types of trials."
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