← Back to Search

Acetaminophen 650 MG for Postoperative Pain

Phase 3

Waitlist Available

Led By Khanh Nguyen, MD

Research Sponsored by Loma Linda University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up first clinic visit after surgery (7 days)

Awards & highlights

Study Summary

This trialtests how well patients feel their care is when given different pain medications after surgery—non-opioid vs opioid.

Eligible Conditions

Postoperative Pain
Pain relief
Patient Satisfaction

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ first clinic visit after surgery (7 days)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~first clinic visit after surgery (7 days)

This trial's timeline: 3 weeks for screening, Varies for treatment, and first clinic visit after surgery (7 days) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Patient satisfaction with post operative pain control

Secondary outcome measures

Efficacy of analgesic regimen and patient attitudes toward treatment they received

Side effects data

From 2019 Phase 1 & 2 trial • 47 Patients • NCT03496545

65%

Blood pressure decrease

46%

Headache

35%

Hypotension required treatment

19%

Orthostasis

12%

Nausea

Hospitalization

100%

80%

60%

40%

20%

Study treatment Arm

Bromocriptine and Acetaminophen

Acetaminophen

Trial Design

3Treatment groups

Experimental Treatment

Group I: Group 3: Ibuprofen and AcetaminophenExperimental Treatment2 Interventions

This group will take Ibuprofen 600mg every 6 hours as needed for pain control If pain is not controlled after 60 minutes then can take Acetaminophen 650mg every 6 hours as needed for additional pain control.

Group II: Group 2: Ibuprofen and Hydrocodone/acetaminophenExperimental Treatment2 Interventions

This group will take Ibuprofen 600mg every 6 hours as needed for pain control If pain is not controlled after 60 minutes then can take Hydrocodone/acetaminophen 5mg/325mg every 6 hours as needed for additional pain control.

Group III: Group 1: Hydrocodone/Acetaminophen and IbuprofenExperimental Treatment2 Interventions

This group will take Hydrocodone/acetaminophen 5mg/325mg every 6 hours as needed for pain control If pain is not controlled after 60 minutes then can take Ibuprofen 600mg every 6 hours as needed for additional pain control.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Hydrocodone

FDA approved

Ibuprofen

FDA approved

Acetaminophen

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Loma Linda UniversityLead Sponsor

306 Previous Clinical Trials

260,838 Total Patients Enrolled

3 Trials studying Postoperative Pain

32 Patients Enrolled for Postoperative Pain

Khanh Nguyen, MDPrincipal Investigator - Loma Linda University Health System

Loma Linda University Children's Hospital, Loma Linda University Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Have any other trials explored the efficacy of Acetaminophen 650 MG?

"The number of active clinical trials for Acetaminophen 650 MG stands at 110, with 33 being in the final Phase 3. The majority are hosted in Pittsburgh, Pennsylvania; however, there are also 1034 other locations carrying out research on this drug."

Answered by AI

In what situations is Acetaminophen 650 MG typically prescribed?

"Acetaminophen 650 MG can effectively address catarrh, rhinorrhea, and muscular discomfort."

Answered by AI

Has the regulatory body sanctioned Acetaminophen 650 MG for therapeutic use?

"Due to the evidence supporting safety and efficacy, Acetaminophen 650 MG was given a rating of 3."

Answered by AI

Are older individuals being sought out to participate in this research?

"This trial is open to people aged between 18 and 89. There are 123 trials available for those under the age of majority, while 551 studies exist for elders over 65 years old."

Answered by AI

Are there any vacancies still available to participate in this clinical trial?

"Per the clinicaltrials.gov website, this medical experiment is actively recruiting patients. The trial was originally posted in July of 2021 and its most recent update occurred at the end of November 2022."

Answered by AI

Do I meet the requirements to take part in this research?

"This trial is open to 200 patients who have undergone some kind of surgery and suffer from pain. Eligible participants must be between 18 and 89 years old, having had a partial or total thyroidectomy, parotidectomy, neck mass excision, facial mass excisioin or cutaneous lesion removal. Other surgical procedures may qualify depending on individual circumstances."

Answered by AI

How many participants are permitted to take part in this experiment?

"Affirmative. The clinical trial is advertising on clinicaltrials.gov and actively looking for participants; the study was posted in July 2021, with updates last occurring in November 2022. 200 patients are sought at a single site of enrollment."

Answered by AI

Recent research and studies

Journal of the American College of SurgeonsJournal

Patient Satisfaction and Pain Control Using an Opioid-sparing Postoperative Pathway

Hallway, Alexander, Joceline Vu, Jay Lee, William Palazzolo, Jennifer Waljee, Chad Brummett, Michael Englesbe, and Ryan Howard. 2019. “Patient Satisfaction and Pain Control Using an Opioid-sparing Postoperative Pathway”. Journal of the American College of Surgeons. Ovid Technologies (Wolters Kluwer Health). doi:10.1016/j.jamcollsurg.2019.04.020.

Plos OneJournal

Opioid Use and Storage Patterns by Patients After Hospital Discharge Following Surgery

Bartels, Karsten, Lena M. Mayes, Colleen Dingmann, Kenneth J. Bullard, Christian J. Hopfer, and Ingrid A. Binswanger. 2016. “Opioid Use and Storage Patterns by Patients After Hospital Discharge Following Surgery”. Edited by Michael Costigan. Plos One. Public Library of Science (PLoS). doi:10.1371/journal.pone.0147972.

clinicaltrials.govStudy

Post Operative Analgesia and Patient Satisfaction

Khanh Nguyen 2021. "Post Operative Analgesia and Patient Satisfaction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04976387.