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Local Anesthetic

Liposomal bupivacaine for Postoperative Pain

Phase 2
Waitlist Available
Research Sponsored by The Cooper Health System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult patients undergoing multilevel lumbar spine surgery, age 18-75
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24-48 hours
Awards & highlights

Study Summary

This study is evaluating whether a superficial nerve block involving the thoracolumbar interfascial plane (TLIP) in reducing postoperative pain in those undergoing spinal surgery. original

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24-48 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24-48 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reduction in postoperative pain
Total postoperative opioid requirements
Secondary outcome measures
Length of Hospital Stay
Time to Ambulation

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Liposomal BupivicaineExperimental Treatment1 Intervention
Administration of a combination of lioposomal bupivicane 20ml/266mg mixed with 20mL of 0.375% bupivicaine
Group II: BupivicaneActive Control1 Intervention
Administration of 40 ml of 0.375% Bupivicaine with epinephrine 1:400,000
Group III: PlaceboPlacebo Group1 Intervention
Saline injection with 40mL preservative-free saline
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupivacaine
FDA approved

Find a Location

Who is running the clinical trial?

The Cooper Health SystemLead Sponsor
75 Previous Clinical Trials
24,023 Total Patients Enrolled
2 Trials studying Postoperative Pain
310 Patients Enrolled for Postoperative Pain

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
AnesthesiologyJournal
Pain Intensity on the First Day After Surgery
Gerbershagen, Hans J., Sanjay Aduckathil, Albert J. M. van Wijck, Linda M. Peelen, Cor J. Kalkman, and Winfried Meissner. 2013. “Pain Intensity on the First Day After Surgery”. Anesthesiology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/aln.0b013e31828866b3.
PeerJJournal
Evaluation of Ultrasound-guided Lateral Thoracolumbar Interfascial Plane Block for Postoperative Analgesia in Lumbar Spine Fusion Surgery: A Prospective, Randomized, and Controlled Clinical Trial
Chen, Ke, Lizhen Wang, Meng Ning, Lianjie Dou, Wei Li, and Yuanhai Li. 2019. “Evaluation of Ultrasound-guided Lateral Thoracolumbar Interfascial Plane Block for Postoperative Analgesia in Lumbar Spine Fusion Surgery: A Prospective, Randomized, and Controlled Clinical Trial”. Peerj. PeerJ. doi:10.7717/peerj.7967.
Canadian Journal of Anesthesia/Journal canadien d'anesthésieJournal
Thoracolumbar Interfascial Plane (TLIP) Block: A Pilot Study in Volunteers
Hand, William R., Jason M. Taylor, Norman R. Harvey, Thomas I. Epperson, Ryan J. Gunselman, Eric D. Bolin, and Joseph Whiteley. 2015. “Thoracolumbar Interfascial Plane (TLIP) Block: A Pilot Study in Volunteers”. Canadian Journal of Anesthesia/journal Canadien D'anesthésie. Springer Science and Business Media LLC. doi:10.1007/s12630-015-0431-y.
Journal of Clinical AnesthesiaJournal
RETRACTED: Thoracolumbar Interfascial Plane Block Provides Effective Perioperative Pain Relief for Patients Undergoing Lumbar Spinal Surgery; a Prospective, Randomized and Double Blinded Trial
Ueshima, Hironobu, Eiko Hara, and Hiroshi Otake. 2019. “RETRACTED: Thoracolumbar Interfascial Plane Block Provides Effective Perioperative Pain Relief for Patients Undergoing Lumbar Spinal Surgery; a Prospective, Randomized and Double Blinded Trial”. Journal of Clinical Anesthesia. Elsevier BV. doi:10.1016/j.jclinane.2019.04.026.
~22 spots leftby Apr 2025
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