Magnesium sulfate for Pain, Postoperative

Phase-Based Estimates
1
Effectiveness
2
Safety
University of Minnesota, Minneapolis, MN
Pain, Postoperative+1 More
Magnesium sulfate - Drug
Eligibility
< 65
All Sexes
Eligible conditions
Pain, Postoperative

Study Summary

This study is evaluating whether magnesium sulfate may help reduce pain in children who have undergone a transplant.

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Eligible Conditions

  • Pain, Postoperative
  • Postoperative Pain

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Magnesium sulfate will improve 1 primary outcome and 3 secondary outcomes in patients with Pain, Postoperative. Measurement will happen over the course of approximately 7 days.

Day 5
Daily Post-operative Opioid Requirement
approximately 7 days
Opioid Side Effects
Requested (PRN) Opioid Use
Total Opioid Requirement

Trial Safety

Safety Estimate

2 of 3
This is better than 68% of similar trials

Trial Design

2 Treatment Groups

Control
Prospective Experimental Group

This trial requires 90 total participants across 2 different treatment groups

This trial involves 2 different treatments. Magnesium Sulfate is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Prospective Experimental Group
Drug
Participants in this group will prospectively receive the intervention.
ControlNo treatment in the control group
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Magnesium sulfate
FDA approved

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: day 1, day 2, day 3, day 4, day 5
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly day 1, day 2, day 3, day 4, day 5 for reporting.

Closest Location

University of Minnesota - Minneapolis, MN

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
- Be scheduled for and receive a liver transplant or total pancreatectomy and islet cell autotransplantation
- Received a liver transplant or total pancreatectomy and islet cell autotransplantation.

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is pain, postoperative?

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Almost all patients consider pain to be either severe or intolerable during postoperative period. The perception of pain level depends on the degree of physical function of the patient. Patients with limited functional capabilities perceive their pain as intolerable.

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What are the signs of pain, postoperative?

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The hallmark of pain is a perception of the pain as painful or intolerable. This pain may be described as the intensity of the pain, the location of the pain, the duration of the pain, and the number of times pain causes the person to be distressed. Pain following total joint arthroplasty may be painful and long-lasting. People typically consider their present pain to be higher than the pain at rest. Pain can be heightened by movement, light touch, or heat. People can describe how their pain is associated with rest, nutrition, family, work, physical activity, exercise, sleep, etc.

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What causes pain, postoperative?

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There are many theories as to the cause of postoperative pain. To date, the best theory that fits the data is that visceral pain fibers are sensitive to inflammatory mediators.

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What are common treatments for pain, postoperative?

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There is a high rate of opioid usage in patients undergoing surgeries, with little evidence of other alternatives. The incidence of paresthesia and wound complications have declined significantly in the past 2 decades. The rate of pain-related hospital stays is low. Thus in our opinion, an alternative to opioids is necessary. We discuss several potential alternatives, as well as the need for randomized trials evaluating these options. A similar approach to the one used for chronic obstructive pulmonary disease may be used for surgical pain on a case-by-case basis.

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How many people get pain, postoperative a year in the United States?

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Each year there are 1.4 million hospitalized patients in the United States. It has been estimated that 8.8 million of these patients experience postoperative pain, which would be about 25%. The incidence of postoperative pain after orthopedic surgery may be greater than 10% and it is likely that the actual incidence is greater than the estimated incidence. Although it is unlikely that such high frequency of postoperative pain might be accounted for by the fact that most patients recover, the postoperative pain following a procedure is a common problem and the incidence of such pain may be underestimated or unrecognized. There is no evidence that the incidence of postoperative pain varies with gender, gender of the surgical procedure or type of surgical hospital.

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Can pain, postoperative be cured?

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There were no differences in the results between the group with postoperative pain and those without. Therefore, there is no role of pain postoperatively in the improvement of the pain.

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What is magnesium sulfate?

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The amount of magnesium sulfate required to offset the postoperative nausea and vomiting is an effective way to reduce the incidence of nausea and vomiting.

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Is magnesium sulfate safe for people?

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Magnesium sulfate is a generally well tolerated medication with few adverse effects. It is associated with an increased rate of postoperative nausea, but there is no evidence that it affects the duration of hospital stay or the overall outcome after surgery.

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Does magnesium sulfate improve quality of life for those with pain, postoperative?

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A single-dose dose of 300 or 600 mg of a 2% MgSO4 solution does not improve quality of life for those with moderate to severe postoperative pain.

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Does pain, postoperative run in families?

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The present study indicated that the risk of pain, postoperative run in families is not substantially greater than the general population, i.e., the prevalence of pain, postoperative run in families in family-based studies and general population-based studies is similar. Nevertheless, the authors suggested that the findings of this study suggested that pain, postoperative run in families for postoperative run in families in family studies and families could be prevented by improving the surgical technique and early postoperative care of patients.

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Who should consider clinical trials for pain, postoperative?

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Patients who are candidates for clinical trials for pain, postoperative pain should be informed of the investigational nature of the clinical trial. If the benefits of a specific treatment option to control pain or modulate postsurgical pain outweigh potential risks, treatment should be explored.

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What is the primary cause of pain, postoperative?

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Results from a recent paper of this study suggest that, for this select group of patients, the causes of pain are varied and often are multi-factorial. It is hoped that the studies will help to formulate a more effective and comprehensive approach to treating postoperative pain.

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