This trial is evaluating whether Magnesium sulfate will improve 1 primary outcome and 3 secondary outcomes in patients with Pain, Postoperative. Measurement will happen over the course of approximately 7 days.
This trial requires 90 total participants across 2 different treatment groups
This trial involves 2 different treatments. Magnesium Sulfate is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
Almost all patients consider pain to be either severe or intolerable during postoperative period. The perception of pain level depends on the degree of physical function of the patient. Patients with limited functional capabilities perceive their pain as intolerable.
The hallmark of pain is a perception of the pain as painful or intolerable. This pain may be described as the intensity of the pain, the location of the pain, the duration of the pain, and the number of times pain causes the person to be distressed. Pain following total joint arthroplasty may be painful and long-lasting. People typically consider their present pain to be higher than the pain at rest. Pain can be heightened by movement, light touch, or heat. People can describe how their pain is associated with rest, nutrition, family, work, physical activity, exercise, sleep, etc.
There are many theories as to the cause of postoperative pain. To date, the best theory that fits the data is that visceral pain fibers are sensitive to inflammatory mediators.
There is a high rate of opioid usage in patients undergoing surgeries, with little evidence of other alternatives. The incidence of paresthesia and wound complications have declined significantly in the past 2 decades. The rate of pain-related hospital stays is low. Thus in our opinion, an alternative to opioids is necessary. We discuss several potential alternatives, as well as the need for randomized trials evaluating these options. A similar approach to the one used for chronic obstructive pulmonary disease may be used for surgical pain on a case-by-case basis.
Each year there are 1.4 million hospitalized patients in the United States. It has been estimated that 8.8 million of these patients experience postoperative pain, which would be about 25%. The incidence of postoperative pain after orthopedic surgery may be greater than 10% and it is likely that the actual incidence is greater than the estimated incidence. Although it is unlikely that such high frequency of postoperative pain might be accounted for by the fact that most patients recover, the postoperative pain following a procedure is a common problem and the incidence of such pain may be underestimated or unrecognized. There is no evidence that the incidence of postoperative pain varies with gender, gender of the surgical procedure or type of surgical hospital.
There were no differences in the results between the group with postoperative pain and those without. Therefore, there is no role of pain postoperatively in the improvement of the pain.
The amount of magnesium sulfate required to offset the postoperative nausea and vomiting is an effective way to reduce the incidence of nausea and vomiting.
Magnesium sulfate is a generally well tolerated medication with few adverse effects. It is associated with an increased rate of postoperative nausea, but there is no evidence that it affects the duration of hospital stay or the overall outcome after surgery.
A single-dose dose of 300 or 600 mg of a 2% MgSO4 solution does not improve quality of life for those with moderate to severe postoperative pain.
The present study indicated that the risk of pain, postoperative run in families is not substantially greater than the general population, i.e., the prevalence of pain, postoperative run in families in family-based studies and general population-based studies is similar. Nevertheless, the authors suggested that the findings of this study suggested that pain, postoperative run in families for postoperative run in families in family studies and families could be prevented by improving the surgical technique and early postoperative care of patients.
Patients who are candidates for clinical trials for pain, postoperative pain should be informed of the investigational nature of the clinical trial. If the benefits of a specific treatment option to control pain or modulate postsurgical pain outweigh potential risks, treatment should be explored.
Results from a recent paper of this study suggest that, for this select group of patients, the causes of pain are varied and often are multi-factorial. It is hoped that the studies will help to formulate a more effective and comprehensive approach to treating postoperative pain.