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1 mL NyDYN Injection for Osteoarthritis

Phase 2
Waitlist Available
Research Sponsored by Illinois Center for Orthopaedic Research and Education
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This study is evaluating whether a single injection of amniotic membrane may help treat knee osteoarthritis.

Eligible Conditions
  • Osteoarthritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Primary Efficacy Endpoints using Validated patient-reported outcome tools questionnaires
Secondary outcome measures
Exploratory Endpoint using Validated patient-reported outcome tools questionnaires

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: 1 mL NyDYN InjectionActive Control1 Intervention
30 patients (out of 90) will be blind to and randomly assigned to a 1 mL NyDYN injection.
Group II: 2 mL NuDYN InjectionActive Control1 Intervention
30 patients (out of 90) will be blind to and randomly assigned to a 2 mL NyDYN injection.
Group III: Placebo of Sterile SalinePlacebo Group1 Intervention
30 patients (out of 90) will be blind to and randomly assigned to a 2 mL dose of sterile saline.

Find a Location

Who is running the clinical trial?

Illinois Center for Orthopaedic Research and EducationLead Sponsor
1 Previous Clinical Trials
1 Trials studying Osteoarthritis
Nikil ChariStudy ChairResearch Assistant
Jacob BarnhartStudy ChairResearch Assistant

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
The American Journal of Sports MedicineJournal
Human Amniotic Membrane–derived Products in Sports Medicine
Riboh, Jonathan C., Bryan M. Saltzman, Adam B. Yanke, and Brian J. Cole. 2016. “Human Amniotic Membrane–derived Products in Sports Medicine”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546515612750.
clinicaltrials.govStudy
An Amniotic Membrane Injection Comparing Two Doses (1 mL and 2 mL Injection) and a Placebo (Sterile Saline) in the Treatment of Osteoarthritis of the Knee
Eyal Ginesin 2020. "An Amniotic Membrane Injection Comparing Two Doses (1 mL and 2 mL Injection) and a Placebo (Sterile Saline) in the Treatment of Osteoarthritis of the Knee". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04612023.
~20 spots leftby Apr 2025
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