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Monoclonal Antibodies

LY3526318 for Osteoarthritis

Phase 2
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 8
Awards & highlights

Study Summary

This study is evaluating whether a drug can help people with knee pain.

Eligible Conditions
  • Osteoarthritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Change From Baseline for Worst Pain Intensity as Measured by NRS
Change From Baseline in Average Pain Intensity as Measured by the Numeric Rating Scale (NRS)
Change From Baseline on the EuroQuality of Life Five Dimensions (5D) Five Level (5L) Questionnaire (EQ-5D-5L) (United States)
+7 more

Side effects data

From 2022 Phase 2 trial • 159 Patients • NCT05086289
3%
Dizziness
3%
Headache
3%
Diarrhoea
3%
Nausea
2%
Somnolence
2%
Vomiting
2%
Fatigue
2%
Vaginal discharge*a
2%
COVID-19
2%
SARS-CoV-2 test positive
1%
Glucose tolerance impaired
1%
Pain
1%
Insomnia
1%
Suicidal ideation
1%
Upper respiratory tract infection
1%
Chest pain
1%
Nasopharyngitis
1%
Bronchitis
1%
Chest discomfort
1%
Dental restoration failure
1%
Hypertriglyceridaemia
1%
Immunisation reaction
1%
Tension headache
1%
Urinary tract infection
1%
Wisdom teeth removal
1%
Hip fracture
1%
Constipation
1%
Musculoskeletal chest pain
1%
Lipoma
1%
Concussion
1%
Anaemia
1%
Post procedural complication
1%
Hypoacusis
1%
Restless legs syndrome
1%
Flatulence
1%
Abdominal distentation
1%
Abdominal pain
1%
Tachycardia
1%
Post procedural haematoma
1%
Photopsia
1%
Frequent bowel movements
1%
Respiratory disorder
1%
Cataract operation
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo Week 1 to 4
250 mg LY3526318 Week 1 to 4
250 mg LY3526318/Placebo Week 5 to 8
Placebo Week 5 to 8

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: LY3526318Experimental Treatment1 Intervention
Participants received 250 mg of LY3526318 orally, once daily for the first 4 weeks and were switched to placebo once daily for the next 4 weeks of the treatment period.
Group II: PlaceboPlacebo Group1 Intervention
Participants received placebo orally, once daily, for 8-weeks treatment period.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LY3526318
2021
Completed Phase 2
~510

Find a Location

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,620 Previous Clinical Trials
3,216,439 Total Patients Enrolled
24 Trials studying Osteoarthritis
5,220 Patients Enrolled for Osteoarthritis
Study DirectorEli Lilly and Company
1,348 Previous Clinical Trials
415,585 Total Patients Enrolled
9 Trials studying Osteoarthritis
2,133 Patients Enrolled for Osteoarthritis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Alabama
Wisconsin
Florida
How old are they?
65+
What site did they apply to?
Simon Williamson Clinic
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis
2021. "Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05080660.
~46 spots leftby Apr 2025
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