Chemotherapy + Reduced-Dose Radiation for Throat Cancer
(ENID Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial will explore giving standard dose chemotherapy and radiation therapy to sites of disease including all lymph nodes involved with HPV-positive oropharyngeal cancer, but administer lower doses of radiation therapy to the lymph nodes that are not known to be involved with cancer. By doing so, it is hypothesized that there will be equally good long term loco-regional and distant disease control but will reduced long term treatment side effects and improved quality of life in persons living well beyond their cancer treatment.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is the combination of chemotherapy and reduced-dose radiation safe for throat cancer?
The combination of chemotherapy (cisplatin) and radiation therapy has been studied for head and neck cancers, showing some safety concerns. Patients experienced severe nausea, vomiting, and other side effects, but overall, the treatment was considered effective and generally well-tolerated in some studies, with gastrointestinal and blood-related side effects being the most common.12345
How is the treatment of chemotherapy combined with reduced-dose radiation for throat cancer different from other treatments?
This treatment is unique because it combines chemotherapy with a reduced dose of radiation, potentially minimizing side effects while maintaining effectiveness. Cisplatin is often used in combination with radiation for head and neck cancers, but this approach specifically aims to reduce radiation exposure, which may lead to fewer long-term complications compared to standard radiation doses.678910
Who Is on the Research Team?
Gregory Biedermann, MD
Principal Investigator
University of Missouri - Ellis Fischel Cancer Center
Are You a Good Fit for This Trial?
This trial is for low-risk patients with HPV-positive oropharyngeal cancer who have not had prior invasive malignancies (except certain skin cancers) in the last 5 years, no previous radiotherapy overlapping the study area, and no chemotherapy for their current cancer. They must be generally healthy, non-heavy smokers or willing to quit, and women of childbearing age should use contraception.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Chemoradiation Treatment
Participants receive concurrent cisplatin and radiation therapy with dose de-escalation to uninvolved lymph nodes
Follow-up
Participants are monitored for safety and effectiveness after treatment, including survival and toxicity profiles
What Are the Treatments Tested in This Trial?
Interventions
- Cisplatin
- Radiation Therapy
Cisplatin is already approved in European Union, United States, Canada, Japan for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Missouri-Columbia
Lead Sponsor