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Corticosteroid

Corticosteroids for Optic Neuritis

Phase 3

Waitlist Available

Research Sponsored by National Eye Institute (NEI)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age range of 18 to 46 years

Acute unilateral optic neuritis with visual symptoms for 8 days or less

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial is investigating whether a corticosteroid drug can help improve vision in people with optic neuritis, as well as any adverse effects of this treatment. The trial will also look at the natural history of vision in patients with optic neuritis, and identify risk factors for developing multiple sclerosis.

Who is the study for?

The ONTT is for individuals aged 18-46 who are experiencing their first episode of optic neuritis, with symptoms like pupil defects and vision loss in one eye lasting no more than 8 days. Candidates should not have other diseases causing the condition or a history of corticosteroid treatment for optic neuritis or multiple sclerosis.Check my eligibility

What is being tested?

This trial evaluates the effects of corticosteroids on optic neuritis to understand how these drugs can help or harm patients. It also aims to track the progression of vision in untreated cases and identify factors that might increase the risk of developing multiple sclerosis after an optic neuritis episode.See study design

What are the potential side effects?

Corticosteroid treatment may lead to side effects such as weight gain, mood swings, increased blood sugar levels, stomach ulcers, bone weakening (osteoporosis), and elevated risk of infections due to immune system suppression.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 46 years old.

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I have had sudden vision problems in one eye for no more than 8 days.

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I have never had optic neuritis in the affected eye.

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I have an eye condition affecting my pupil's reaction and field of vision.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Eye Institute (NEI)Lead Sponsor

546 Previous Clinical Trials

1,401,928 Total Patients Enrolled

3 Trials studying Optic Neuritis

8 Patients Enrolled for Optic Neuritis

Media Library

Corticosteroid (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT00000146 — Phase 3

Optic Neuritis Clinical Trial 2023: Corticosteroid Highlights & Side Effects. Trial Name: NCT00000146 — Phase 3

Corticosteroid (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00000146 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this test allow for elderly participants?

"Individuals aged 18 to 46 who meet the other specified inclusion criteria can apply for this clinical trial. In contrast, there are 27 trials available for patients under 18 and 263 studies recruiting people over 65."

Answered by AI

How risky is this proposed course of treatment for patients?

"There is some clinical data suggesting this intervention's efficacy, and it has undergone multiple rounds of testing to verify its safety. Therefore, our team rates the safety of this treatment as a 3."

Answered by AI