← Back to Search

GLP-1 Receptor Agonist

Phentermine-Topiramate for Obesity

Q: What is the most common use for Phentermine-Topiramate?

<p>Phentermine-Topiramate can be used to manage <a href="https://www.withpower.com/clinical-trials/diabetes">diabetes</a>, <a href="https://www.withpower.com/clinical-trials/adhd">ADHD</a>, and help people quit <a href="https://www.withpower.com/clinical-trials/smoking">smoking</a> cigarettes.</p>

Phase 3

Waitlist Available

Led By Andres J Acosta

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adults with obesity (BMI >30 Kg/m2); these will be otherwise healthy individuals with no unstable psychiatric disease and controlled comorbidities or other diseases.

Gender: Men or women. Women of childbearing potential will have negative pregnancy tests within 48 hours of enrollment and before each radiation exposure.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to 12 weeks

Awards & highlights

Study Summary

This trial is testing whether weight loss medications are more effective when tailored to an individual's specific characteristics.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

The adults with obesity will have no unstable psychiatric disease, controlled comorbidities, or other diseases.

Select...

The women of childbearing potential will have a negative pregnancy test within 48 hours of enrollment and before each radiation exposure.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to 12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Total Body Weight

Secondary outcome measures

Percentage of Responders

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Intervention groupExperimental Treatment3 Interventions

Phenotype-guided pharmacotherapy, which includes Phentermine-Topiramate, Liraglutide, Naltrexone/bupropion or Phentermine plus Exercise

Group II: Control GroupActive Control4 Interventions

Randomly assigned pharmacotherapy, which includes Phentermine-Topiramate, Liraglutide, Naltrexone/bupropion or Phentermine

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Phentermine-Topiramate

2017

Completed Phase 3

~200

Liraglutide

2013

Completed Phase 4

~2680

Naltrexone/bupropion

2017

Completed Phase 3

~200

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,207 Previous Clinical Trials

3,766,947 Total Patients Enrolled

84 Trials studying Obesity

14,530 Patients Enrolled for Obesity

Andres J AcostaPrincipal InvestigatorMayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients being actively recruited for this research project?

"As can be seen on clinicaltrials.gov, this particular trial is no longer looking for participants. The study was originally posted on December 11th 2017 but has not been updated since July 19th 2022. There are, however, 1,119 other trials that are currently seeking patients."

Answered by AI

How can I sign up for this clinical trial?

"This study requires that potential patients be obese and between 18-75 years old. Out of the 200 total people that will be accepted, how many will you admit?"

Answered by AI

If a patient is under 45, do they qualify for this clinical trial?

"According to the eligibility requirements set out by the study, patients must be aged between 18-75. There are currently 224 trials underway for patients that fall under the age of 18 and 702 for senior citizens aged 65 and up."

Answered by AI

How many people are allowed to enroll in this research project?

"Unfortunately, this trial is no longer recruiting patients. Although the study's last update was on July 19th, 2022, it is now closed to new participants. However, there are 998 other trials for obesity and 121 for Phentermine-Topiramate that are still open."

Answered by AI

What is the most common use for Phentermine-Topiramate?

"Phentermine-Topiramate can be used to manage diabetes, ADHD, and help people quit smoking cigarettes."

Answered by AI

What are the potential risks associated with Phentermine-Topiramate?

"This medication, which is currently in Phase 3 clinical trials, has received a score of 3 for safety. This reflects both the efficacy data collected thus far as well as the multiple rounds of tests performed to ensure Phentermine-Topiramate's safety."

Answered by AI