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Thiazolidinedione

1 for Non-alcoholic Fatty Liver Disease

Phase 2
Waitlist Available
Led By Dawn M Torres, MD
Research Sponsored by Brooke Army Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up throughout study (ongoing)
Awards & highlights

Study Summary

The purpose of this study is to evaluate the efficacy of rosiglitazone alone compared with rosiglitazone plus metformin or rosiglitazone plus losartan in the treatment of biopsy proven nonalcoholic steatohepatitis (NASH). This study was designed to answer the question: are there differences in the efficacy (as measured by histopathology and insulin resistance) of three different therapeutic modalities used to treat NASH?

Eligible Conditions
  • Non-alcoholic Fatty Liver Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~end of study
This trial's timeline: 3 weeks for screening, Varies for treatment, and end of study for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
liver biopsy histologic improvement
Secondary outcome measures
serum transaminases

Trial Design

3Treatment groups
Experimental Treatment
Group I: 3Experimental Treatment2 Interventions
avandia plus losartan
Group II: 2Experimental Treatment2 Interventions
avandia plus metformin
Group III: 1Experimental Treatment1 Intervention
avandia
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Metformin
FDA approved
Losartan
FDA approved

Find a Location

Who is running the clinical trial?

Brooke Army Medical CenterLead Sponsor
119 Previous Clinical Trials
26,394 Total Patients Enrolled
2 Trials studying Non-alcoholic Fatty Liver Disease
478 Patients Enrolled for Non-alcoholic Fatty Liver Disease
Dawn M Torres, MDPrincipal InvestigatorBrooke Army Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH)
2007. "Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00699036.
All > Autoimmune Hepatitis > Nash
~9 spots leftby Apr 2025
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